Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.51 |
| ▸ | TYK2 | P29597 | 7/20 | 0.51 |
| ▸ | AURKA | O14965 | 7/20 | 0.51 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GCK | P35557 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3516179 | 0.86 | AURKA (0.68) | JAK2TYK2AURKAAURKBNPC1 | |
| SCHEMBL3514991 | 0.85 | JAK2 (0.49) | JAK2TYK2AURKAAURKBNPC1 | |
| SCHEMBL5236720 | 0.84 | HCAR3 (0.66) | JAK2TYK2HCAR3NPC1RAB9A | |
| SCHEMBL3514123 | 0.82 | TYK2 (0.65) | JAK2TYK2AURKAAURKBNPC1 | |
| SCHEMBL3515487 | 0.82 | AURKA (0.71) | JAK2TYK2AURKAAURKBNPC1 | |
| SCHEMBL3515247 | 0.81 | JAK2 (0.64) | JAK2TYK2AURKAAURKBNPC1 | |
| SCHEMBL12987231 | 0.80 | TYK2 (0.71) | JAK2TYK2JAK1 | |
| SCHEMBL3514479 | 0.80 | JAK2 (0.52) | JAK2TYK2HCAR3RAB9AGCK | |
| SCHEMBL3514256 | 0.78 | JAK2 (0.54) | JAK2TYK2AURKAAURKBJAK1 | |
| SCHEMBL3513072 | 0.78 | TYK2 (0.62) | JAK2TYK2AURKAAURKBJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486950-B2 | Janus kinase inhibitor compounds and methods | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-16 | — | — | US | disclosed |
| US-8486950-B2 | Janus kinase inhibitor compounds and methods | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-16 | — | — | US | disclosed |
| US-8486950-B2 | Janus kinase inhibitor compounds and methods | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-16 | — | — | US | disclosed |
| WO-2010142752-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-16 | — | — | WO | disclosed |
| US-20100317643-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100317643-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100317643-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317643-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | JAK2, JAK1, JAK3 | JAK2 1/4885TYK2 21/4885AURKA 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.