Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.65 |
| ▸ | OTC | P00480 | 1/20 | 0.49 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.48 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.48 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.48 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.46 |
| ▸ | NOS2 | P35228 | 5/20 | 0.44 |
| ▸ | NOS3 | P29474 | 3/20 | 0.44 |
| ▸ | NOS1 | P29475 | 3/20 | 0.44 |
| ▸ | ARG2 | P78540 | 4/20 | 0.42 |
| ▸ | ARG1 | P05089 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL27968247 | 1.00 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL2143365 | 1.00 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL292022 | 1.00 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL301606 | 1.00 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL8957537 | 1.00 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL11660904 | 1.00 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL714211 | 1.00 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL4954180 | 1.00 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL15022773 | 1.00 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL27641260 | 1.00 | GSR (0.65) | GSROTCGNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020025918-A1 | Methods of using helical peptides in plants | HELIX BIOMEDIX, INC. | 2002-02-28 | — | — | US | claimed |
| US-6255282-B1 | KILLING MICROORGANISMS | HELIX BIOMEDIX, INC. | 2001-07-03 | — | — | US | claimed |
| EP-2396033-B1 | INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS | MEDIMMUNE LLC (US) | 2016-09-28 | — | — | EP | disclosed |
| US-9119812-B2 | Influenza hemagglutinin and neuraminidase variants | MEDIMMUNE, LLC (US) | 2015-09-01 | — | — | US | disclosed |
| US-20140079726-A1 | INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS | MEDIMMUNE, LLC (US) | 2014-03-20 | — | — | US | disclosed |
| US-8613935-B2 | Influenza hemagglutinin and neuraminidase variants | MEDIMMUNE, LLC (US) | 2013-12-24 | — | — | US | disclosed |
| US-20100330118-A1 | INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS | MEDIMMUNE, LLC (US) | 2010-12-30 | — | — | US | disclosed |
| WO-2010093537-A2 | INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS | MEDIMMUNE, LLC (US) | 2010-08-19 | — | — | WO | disclosed |
| US-5506206-A | ARGININE-PROLINE-HYDROXYPROLINE-GLYCINE-THIENYLALANINE-SERINE -(4-METHYL-TYROSINE)-ARGANINE OR A CONFORMATIONAL ANALOGUE, USED AS THERAPEUTICAL OR DIAGNOSTIC AGENTS | ALKERMES, INC. (US) | 1996-04-09 | — | — | US | disclosed |