⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2066790 | 0.80 | EIF4E (0.30) | — | |
| SCHEMBL3515184 | 0.80 | — | — | |
| SCHEMBL2068124 | 0.75 | PDE4A (0.35) | — | |
| SCHEMBL2067581 | 0.73 | AOC3 (0.32) | — | |
| SCHEMBL2066762 | 0.65 | ALDH1A1 (0.30) | — | |
| SCHEMBL2489208 | 0.64 | — | — | |
| SCHEMBL10366901 | 0.64 | — | — | |
| SCHEMBL2066983 | 0.62 | — | — | |
| SCHEMBL2069483 | 0.60 | — | — | |
| SCHEMBL2068436 | 0.60 | KDM4E (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140005163-A1 | 1H-IMIDAZO[4,5-C]QUINOLINONE DERIVATIVES | NOVARTIS AG (CH) | 2014-01-02 | — | — | US | disclosed |
| US-8476294-B2 | 1H-imidazo[4,5-c]quinolinone derivatives | NOVARTIS AG (CH) | 2013-07-02 | — | — | US | disclosed |
| US-20100317657-A1 | 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES | NOVARTIS AG | 2010-12-16 | — | — | US | disclosed |