Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.60 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 16/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 16/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 12/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.56 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4954196 | 0.88 | ADORA2A (0.61) | HSP90AA1HSP90AB1ADORA2AADORA1ADORA2B | |
| SCHEMBL13731182 | 0.82 | ADORA2A (0.58) | HSP90AA1HSP90AB1ADORA2AADORA1ADORA2B | |
| SCHEMBL3746480 | 0.81 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1ADORA2AADORA1ADORA2B | |
| SCHEMBL3515942 | 0.81 | ADORA2A (0.56) | HSP90AA1HSP90AB1ADORA2AADORA1ADORA2B | |
| SCHEMBL3111832 | 0.80 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1ADORA2AADORA1ADORA2B | |
| SCHEMBL13845675 | 0.78 | HSP90AA1 (0.77) | HSP90AA1HSP90AB1 | |
| SCHEMBL27774220 | 0.77 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1ADORA2AADORA1ADORA2B | |
| SCHEMBL3517082 | 0.77 | HSP90AA1 (0.76) | HSP90AA1HSP90AB1 | |
| SCHEMBL3516432 | 0.76 | ADORA2A (0.56) | ADORA2AADORA1ADORA2B | |
| SCHEMBL3119723 | 0.76 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2219448-A1 | THERAPEUTIC COMPOUNDS AND THEIR USE IN TREATING DISEASES AND DISORDERS | Myriad Pharmaceuticals, Inc. (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009065035-A1 | THERAPEUTIC COMPOUNDS AND THEIR USE IN TREATING DISEASES AND DISORDERS | MYRIAD GENETICS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |
| WO-2009065035-A1 | THERAPEUTIC COMPOUNDS AND THEIR USE IN TREATING DISEASES AND DISORDERS | MYRIAD GENETICS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |