Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.56 |
| ▸ | PI4KA | P42356 | 2/20 | 0.51 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.51 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.51 |
| ▸ | NSD3 | Q9BZ95 | 6/20 | 0.47 |
| ▸ | NSD2 | O96028 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13731483 | 0.81 | ADORA2A (0.56) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL3520367 | 0.80 | ADORA2A (0.51) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL4438894 | 0.80 | ADORA2A (0.53) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL4438238 | 0.80 | ADORA2A (0.53) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL3520144 | 0.79 | ADORA2A (0.53) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL28097097 | 0.79 | ADORA2A (0.52) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL11222112 | 0.78 | ADORA2A (0.80) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL3520240 | 0.76 | SRC (0.38) | PI4KBLMNA | |
| SCHEMBL7436925 | 0.76 | ADORA2A (0.58) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL3517140 | 0.76 | HSP90AA1 (0.60) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2219448-A1 | THERAPEUTIC COMPOUNDS AND THEIR USE IN TREATING DISEASES AND DISORDERS | Myriad Pharmaceuticals, Inc. (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009065035-A1 | THERAPEUTIC COMPOUNDS AND THEIR USE IN TREATING DISEASES AND DISORDERS | MYRIAD GENETICS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |