Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.61 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.43 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.43 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.43 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 9/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 5/20 | 0.42 |
| ▸ | DPP4 | P27487 | 3/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | ARG1 | P05089 | 1/20 | 0.36 |
| ▸ | ARG2 | P78540 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL1281704 | 0.95 | GSR (0.61) | GSRRNPEPGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL5691382 | 0.95 | GSR (0.61) | GSRRNPEPGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL5148145 | 0.95 | GSR (0.61) | GSRRNPEPGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL5062296 | 0.95 | GSR (0.61) | GSRRNPEPGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL3739868 | 0.95 | GSR (0.61) | GSRRNPEPGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL25283016 | 0.95 | GSR (0.61) | GSRRNPEPGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL121844 | 0.95 | GSR (0.61) | GSRRNPEPGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL3749535 | 0.95 | GSR (0.61) | GSRRNPEPGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL5691386 | 0.95 | GSR (0.61) | GSRRNPEPGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL4400353 | 0.95 | GSR (0.61) | GSRRNPEPGNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180481-B2 | Oxopiperazine helix mimetics as inhibitors of the p53-MDM2 interaction | NEW YORK UNIVERSITY (US) | 2021-11-23 | — | — | US | disclosed |
| CN-101855336-B | Pharmaceutical composition containing clostridium difficile toxoids A and B | 赛诺菲巴斯德生物制剂有限责任公司 | 2019-07-30 | — | — | CN | disclosed |
| US-20170037033-A1 | OXOPIPERAZINE HELIX MIMETICS AS INHIBITORS OF THE p53-MDM2 INTERACTION | NEW YORK UNIVERSITY (US) | 2017-02-09 | — | — | US | disclosed |
| WO-2015160914-A1 | OXOPIPERAZINE HELIX MIMETICS AS INHIBITORS OF THE p53-MDM2 INTERACTION | NEW YORK UNIVERSITY (US) | 2015-10-22 | — | — | WO | disclosed |
| US-20100297697-A1 | METHODS FOR INCREASING PROTEIN TITERS | BOEHRINGER INGELHEIM PHARMA GMBH & CO KG (DE) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037033-A1 | OXOPIPERAZINE HELIX MIMETICS AS INHIBITORS OF THE p53-MDM2 INTERACTION | TP53, MDM2, TP53BP1 | GSR 2240/4885RNPEP 1381/4885GNAI3 2336/4885 |
| US-11180481-B2 | Oxopiperazine helix mimetics as inhibitors of the p53-MDM2 interaction | TP53, MDM2, TP53BP1 | GSR 2990/4885RNPEP 1934/4885GNAI3 1925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.