⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5694387 | 0.78 | — | — | |
| SCHEMBL16213438 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL3660366 | 0.70 | — | — | |
| SCHEMBL5750932 | 0.68 | — | — | |
| SCHEMBL8144229 | 0.64 | — | — | |
| SCHEMBL998763 | 0.63 | — | — | |
| SCHEMBL9131788 | 0.62 | — | — | |
| SCHEMBL951944 | 0.62 | — | — | |
| SCHEMBL10933497 | 0.62 | — | — | |
| SCHEMBL1915524 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140369934-A1 | dsRNA/DNA Hybrid Genome Replication Intermediate Of Metakaryotic Stem Cells | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2014-12-18 | — | — | US | disclosed |
| WO-2012167011-A1 | DSRNA/DNA HYBRID GENOME REPLICATION INTERMEDIATE OF METAKARYOTIC STEM CELLS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-12-06 | — | — | WO | disclosed |
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
| EP-2044068-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | Merck & Co., Inc. (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008010964-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK & CO., INC. (US) | 2008-01-24 | — | — | WO | disclosed |