Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.35 |
| ▸ | TUBB | P07437 | 3/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.35 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.35 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.35 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.35 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3521139 | 0.88 | TSHR (0.38) | HPGDTACR3SMPD3CYP1A1CYP1A2 | |
| SCHEMBL3525976 | 0.86 | CTSA (0.39) | HPGDTACR3CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL3519874 | 0.78 | MEN1 (0.49) | HPGDTACR3MAPTSMN1; SMN2TSHR | |
| SCHEMBL3520838 | 0.77 | HPGD (0.42) | HPGDTACR3SMPD3CYP3A4CYP2C9 | |
| SCHEMBL3524365 | 0.75 | MEN1 (0.48) | HPGDTACR3MAPTSMN1; SMN2 | |
| SCHEMBL3516674 | 0.74 | SMN1; SMN2 (0.46) | HPGDCYP1A2CYP3A4CYP2C9MAPT | |
| SCHEMBL3530230 | 0.72 | EGLN3 (0.50) | HPGDTACR3CYP3A4CYP2C9PKMYT1 | |
| SCHEMBL3521337 | 0.72 | MEN1 (0.47) | HPGDTACR3MAPTSMN1; SMN2TSHR | |
| SCHEMBL3517714 | 0.72 | ALDH1A1 (0.42) | CYP3A4MAPTSMN1; SMN2 | |
| SCHEMBL3520781 | 0.72 | EGLN3 (0.38) | HPGDTACR3CYP3A4CYP2C9PKMYT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305133-A1 | Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2010-12-02 | — | — | US | disclosed |
| EP-2227770-A2 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073497-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305133-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN3, EGLN2 | HPGD 51/4885TACR3 4715/4885SMPD3 2123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.