Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.56 |
| ▸ | CHUK | O15111 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.55 |
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.47 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3516525 | 0.95 | EPHX2 (0.61) | IKBKBCHUKEPHX2JAK2CDK4 | |
| SCHEMBL3522490 | 0.90 | JAK2 (0.51) | IKBKBEPHX2JAK2KMT2ACDK4 | |
| SCHEMBL3519561 | 0.89 | JAK2 (0.59) | IKBKBCHUKJAK2KMT2ACDK4 | |
| SCHEMBL3518248 | 0.89 | JAK2 (0.56) | IKBKBCHUKJAK2KMT2ACDK4 | |
| SCHEMBL3522180 | 0.87 | JAK2 (0.54) | IKBKBJAK2KMT2ACDK4CDK2 | |
| SCHEMBL3516458 | 0.87 | POLB (0.59) | IKBKBCHUKJAK2KMT2ACDK4 | |
| SCHEMBL3521529 | 0.87 | IKBKB (0.54) | IKBKBJAK2KMT2ACDK4CDK2 | |
| SCHEMBL3521975 | 0.86 | POLB (0.54) | IKBKBCHUKJAK2KMT2ACDK4 | |
| SCHEMBL3520398 | 0.85 | JAK2 (0.57) | IKBKBCHUKJAK2CDK4CDK2 | |
| SCHEMBL3520074 | 0.85 | JAK2 (0.53) | IKBKBCHUKEPHX2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | claimed |
| US-20060079543-A1 | Anilino-pyrimidine analogs | WYETH (US) | 2006-04-13 | — | — | US | claimed |
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | disclosed |
| US-20060079543-A1 | Anilino-pyrimidine analogs | WYETH (US) | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079543-A1 | Anilino-pyrimidine analogs | DPYD, TYMP, ADORA3 | IKBKB 3246/4885CHUK 2096/4885EPHX2 2137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.