Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16211023 | 0.93 | MEN1 (0.39) | MEN1KMT2AALDH1A1LMNACYP1A2 | |
| SCHEMBL283884 | 0.92 | MEN1 (0.46) | MEN1KMT2AALDH1A1LMNACYP1A2 | |
| SCHEMBL6451149 | 0.91 | MEN1 (0.40) | MEN1KMT2AALDH1A1LMNACYP1A2 | |
| SCHEMBL4740338 | 0.86 | MEN1 (0.42) | MEN1KMT2AALDH1A1LMNACYP1A2 | |
| SCHEMBL4424463 | 0.86 | MEN1 (0.42) | MEN1KMT2AALDH1A1LMNACYP1A2 | |
| SCHEMBL28559339 | 0.85 | MEN1 (0.44) | MEN1KMT2AALDH1A1LMNACYP1A2 | |
| SCHEMBL12933672 | 0.83 | MEN1 (0.40) | MEN1KMT2AALDH1A1LMNACYP1A2 | |
| SCHEMBL13755066 | 0.83 | MEN1 (0.43) | MEN1KMT2AALDH1A1LMNACYP1A2 | |
| SCHEMBL9695816 | 0.82 | MEN1 (0.42) | MEN1KMT2AALDH1A1LMNACYP1A2 | |
| SCHEMBL21359810 | 0.82 | MEN1 (0.42) | MEN1KMT2AALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183275-B2 | Substituted imidazoles as bombesin receptor subtype-3 modulators | MERCK SHARP & DOHME CORP. (US) | 2012-05-22 | — | — | US | disclosed |
| US-20100204236-A1 | Substituted imidazoles as bombesin receptor subtype-3 modulators | MERCK SHARP & DOHME CORP. | 2010-08-12 | — | — | US | disclosed |
| EP-2083623-A1 | SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS | Merck & Co., Inc. (US) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008051405-A1 | SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS | MERCK & CO., INC. (US) | 2008-05-02 | — | — | WO | disclosed |
| US-5110914-A | Ion exchanging | UNIVERSITY OF MIAMI (US) | 1992-05-05 | — | — | US | disclosed |
| US-5086167-A | Ion exchanging with a ligand/matrix using a combination of pi-electron and electrostatic interaction of the ligand and ionic amino acids | UNIVERSITY OF MIAMI (US) | 1992-02-04 | — | — | US | disclosed |
| EP-0371746-A2 | Method of separating proteins | UNIVERSITY OF MIAMI (US) | 1990-06-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204236-A1 | Substituted imidazoles as bombesin receptor subtype-3 modulators | BRS3, GPR119, GIPR | MEN1 764/4885KMT2A 4157/4885ALDH1A1 4808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.