Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 5/20 | 0.50 |
| ▸ | CNR2 | P34972 | 5/20 | 0.49 |
| ▸ | CNR1 | P21554 | 3/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3516443 | 0.95 | CNR2 (0.51) | IKBKBCNR2CNR1PIK3CAPIK3CG | |
| SCHEMBL3521916 | 0.89 | IKBKB (0.47) | IKBKBCNR2CNR1CDK2CDC7 | |
| SCHEMBL3518123 | 0.87 | IKBKB (0.52) | IKBKBPIK3CAPIK3CGPIK3CBCDK5 | |
| SCHEMBL3522470 | 0.87 | PIK3CG (0.54) | IKBKBPIK3CAPIK3CGPIK3CBCDK5 | |
| SCHEMBL3520096 | 0.84 | IKBKB (0.49) | IKBKBCNR2CNR1CDK2CDC7 | |
| SCHEMBL3522392 | 0.83 | IKBKB (0.70) | IKBKBPIK3CAPIK3CGPIK3CBMEN1 | |
| SCHEMBL3518027 | 0.82 | IKBKB (0.53) | IKBKBPIK3CAPIK3CGPIK3CBCDK5 | |
| SCHEMBL3516351 | 0.82 | IKBKB (0.53) | IKBKBPIK3CAPIK3CGPIK3CBCDK5 | |
| SCHEMBL3516460 | 0.82 | PIK3CG (0.60) | IKBKBPIK3CAPIK3CGPIK3CBGSK3B | |
| SCHEMBL3516749 | 0.79 | IKBKB (0.51) | IKBKBPIK3CAPIK3CGPIK3CBCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | claimed |
| EP-1799652-A1 | N-BENZENESULFONYL SUBSTITUTED ANILINO-PYRIMIDINE ANALOGS | Wyeth (US) | 2007-06-27 | — | — | EP | claimed |
| WO-2006044457-A1 | N-BENZENESULFONYL SUBSTITUTED ANILINO-PYRIMIDINE ANALOGS | WYETH (US) | 2006-04-27 | — | — | WO | claimed |