Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.51 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3516845 | 0.84 | EGLN3 (0.57) | NPC1RAB9APDGFRBPDGFRARHOA | |
| SCHEMBL3582712 | 0.81 | PDGFRB (0.46) | NPC1PDGFRBPDGFRAKDM4EMEN1 | |
| SCHEMBL3521287 | 0.76 | ABL1 (0.45) | NPC1RAB9APDGFRBKDM4ESMN1; SMN2 | |
| SCHEMBL3754497 | 0.76 | PDGFRB (0.56) | NPC1RAB9APDGFRBPDGFRARHOA | |
| SCHEMBL3517219 | 0.74 | CA12 (0.37) | KDM4EALDH1A1AURKAAURKB | |
| SCHEMBL3520596 | 0.74 | PKMYT1 (0.39) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3530024 | 0.73 | HTT (0.51) | NPC1RAB9ARHOAKDM4EMEN1 | |
| SCHEMBL3735695 | 0.71 | ALDH1A1 (0.56) | RAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL29381124 | 0.71 | ALDH1A1 (0.56) | RAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL1401437 | 0.70 | PDGFRB (0.68) | NPC1RAB9APDGFRBPDGFRARHOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305133-A1 | Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2010-12-02 | — | — | US | disclosed |
| EP-2227770-A2 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073497-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305133-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN3, EGLN2 | NPC1 2674/4885RAB9A 3111/4885PDGFRB 975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.