SCHEMBL35210274

SCHEMBL35210274

C=CC(=O)Nc1cc(Nc2cc(Nc3ccc(F)c(Cl)c3)ncn2)c(OC)cc1N1CCC(N2CCOCC2)CC1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 20/20 0.58
ERBB3 P21860 3/20 0.52
DUS2 Q9NX74 1/20 0.52
ERBB2 P04626 4/20 0.49
KIT P10721 2/20 0.49
SRC P12931 2/20 0.49
ERBB4 Q15303 2/20 0.49
BMPR1B O00238 1/20 0.49
CIT O14578 1/20 0.49
MAP2K7 O14733 1/20 0.49
GAK O14976 1/20 0.49
EPHB6 O15197 1/20 0.49
MAP3K7 O43318 1/20 0.49
RIPK2 O43353 1/20 0.49
STK17B O94768 1/20 0.49
STK10 O94804 1/20 0.49
ABL1 P00519 1/20 0.49
LCK P06239 1/20 0.49
FYN P06241 1/20 0.49
YES1 P07947 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19089508 1.00 EGFR (0.58) EGFRERBB3DUS2ERBB2KIT
SCHEMBL35210297 0.92 EGFR (0.52) EGFRERBB3DUS2ALK
SCHEMBL19089507 0.92 EGFR (0.52) EGFRERBB3DUS2ALK
SCHEMBL20548791 0.88 EGFR (0.57) EGFRERBB3DUS2ERBB2SRC
SCHEMBL35210310 0.88 EGFR (0.57) EGFRERBB3DUS2ERBB2SRC
SCHEMBL19089514 0.88 EGFR (0.58) EGFRERBB3DUS2ERBB2JAK3
SCHEMBL35210302 0.88 EGFR (0.58) EGFRERBB3DUS2ERBB2JAK3
SCHEMBL19089342 0.87 EGFR (0.56) EGFR
SCHEMBL19089518 0.86 EGFR (0.55) EGFRERBB3DUS2ERBB2
SCHEMBL35210275 0.86 EGFR (0.55) EGFRERBB3DUS2ERBB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3398939-B1 ACRYLANILIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN PHARMACY ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) 2026-05-06 EP claimed
EP-3398939-B1 ACRYLANILIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN PHARMACY ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) 2026-05-06 EP disclosed