SCHEMBL35210325

SCHEMBL35210325

C=CC(=O)Nc1cc(Nc2ncnc(Nc3cccc(Cl)c3)n2)c(OC)cc1N(C)CCN(C)C

nearest known ligand 0.64

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
EGFR P00533 20/20 0.64
ALK Q9UM73 4/20 0.62
EML4 Q9HC35 3/20 0.62
KCNH2 Q12809 3/20 0.61
IGF1R P08069 2/20 0.61
INSR P06213 2/20 0.60
ERBB2 P04626 1/20 0.60
ROS1 P08922 1/20 0.60
FER P16591 1/20 0.60
LTK P29376 1/20 0.60
BLK P51451 1/20 0.60
PTK2 Q05397 1/20 0.60
BTK Q06187 1/20 0.60
TNK2 Q07912 1/20 0.60
ERBB4 Q15303 1/20 0.60
SLK Q9H2G2 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19089586 1.00 EGFR (0.64) EGFRALKEML4KCNH2IGF1R
SCHEMBL19089366 0.92 EGFR (0.73) EGFRALKEML4KCNH2PTK2
SCHEMBL19089588 0.91 EGFR (0.65) EGFRALKEML4KCNH2PTK2
SCHEMBL20548861 0.91 EGFR (0.64) EGFRALKEML4KCNH2
SCHEMBL20548920 0.91 EGFR (0.68) EGFRALKEML4KCNH2
SCHEMBL19089589 0.89 EGFR (0.62) EGFRALKEML4KCNH2IGF1R
SCHEMBL19089594 0.88 EGFR (0.70) EGFRALKEML4KCNH2
SCHEMBL19089596 0.87 EGFR (0.66) EGFRALKEML4KCNH2IGF1R
SCHEMBL19089597 0.84 EGFR (0.63) EGFRALKEML4KCNH2IGF1R
SCHEMBL24251692 0.84 EGFR (0.69) EGFRALKEML4KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3398939-B1 ACRYLANILIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN PHARMACY ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) 2026-05-06 EP disclosed