Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 5/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 14/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3516672 | 0.93 | EGLN3 (0.54) | EGLN3EGLN1EGLN2FTOAPEX1 | |
| SCHEMBL3567141 | 0.83 | PTPN1 (0.45) | EGLN3 | |
| SCHEMBL3521948 | 0.81 | EGLN3 (0.57) | EGLN3EGLN1EGLN2FTOAPEX1 | |
| SCHEMBL3518770 | 0.80 | EGLN3 (0.61) | EGLN3EGLN1EGLN2FTO | |
| SCHEMBL3521209 | 0.80 | EGLN3 (0.61) | EGLN3EGLN1EGLN2FTOAPEX1 | |
| SCHEMBL3520304 | 0.80 | EGLN3 (0.61) | EGLN3EGLN1EGLN2FTOAPEX1 | |
| SCHEMBL3523045 | 0.79 | EGLN3 (0.57) | EGLN3EGLN1EGLN2FTOAPEX1 | |
| SCHEMBL3763287 | 0.77 | EGLN3 (0.70) | EGLN3EGLN1EGLN2FTO | |
| SCHEMBL3522213 | 0.76 | EGLN3 (0.83) | EGLN3EGLN1EGLN2FTO | |
| SCHEMBL3758545 | 0.75 | EGLN3 (0.74) | EGLN3EGLN1EGLN2FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227770-A2 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-15 | — | — | EP | claimed |
| WO-2009073497-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | claimed |
| EP-2227770-A2 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073497-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |