Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 3/20 | 0.38 |
| ▸ | LDHB | P07195 | 3/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.37 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.33 |
| ▸ | BID | P55957 | 3/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.33 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3521952 | 0.83 | EGLN3 (0.56) | EGLN3 | |
| SCHEMBL3516672 | 0.76 | EGLN3 (0.54) | EGLN3 | |
| SCHEMBL3567138 | 0.76 | FABP3 (0.42) | LDHALDHBEGLN3MCL1 | |
| SCHEMBL3519604 | 0.73 | KDM4E (0.45) | PTPN1PTPN2EGLN3 | |
| SCHEMBL3521085 | 0.73 | DPP4 (0.44) | KDM5AEGLN3 | |
| SCHEMBL3520296 | 0.73 | EGLN3 (0.37) | EGLN3 | |
| SCHEMBL3520015 | 0.72 | MAPK8 (0.39) | DHFRPPARGPPARA | |
| SCHEMBL19841048 | 0.71 | PRKCI (0.37) | PRKCIHCAR2DAGLABIDMCL1 | |
| SCHEMBL15782884 | 0.71 | PRKCI (0.35) | PRKCIEGLN3 | |
| SCHEMBL11793048 | 0.69 | F2RL1 (0.34) | PTPN1PTPN11KDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227770-A2 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073497-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |