Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.49 |
| ▸ | NPC1 | O15118 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.49 |
| ▸ | RELA | Q04206 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL866607 | 0.81 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL28615412 | 0.76 | NPC1 (0.49) | RAB9ANPC1SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL1877283 | 0.76 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL28597061 | 0.73 | NPC1 (0.54) | RAB9ANPC1SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL22888354 | 0.73 | TSHR (0.59) | RAB9ANPC1SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL2399420 | 0.73 | NPC1 (0.57) | RAB9ANPC1SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL308631 | 0.72 | — | — | |
| SCHEMBL308630 | 0.72 | — | — | |
| SCHEMBL526662 | 0.72 | SMN1; SMN2 (0.58) | RAB9ANPC1SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL9337819 | 0.72 | RAB9A (0.61) | RAB9ANPC1SMN1; SMN2MAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2241567-A1 | BICYCLOAMINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2010-10-20 | — | — | EP | disclosed |