Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 13/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 13/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 12/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 11/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 11/20 | 0.46 |
| ▸ | MINK1 | Q8N4C8 | 10/20 | 0.46 |
| ▸ | PRKD2 | Q9BZL6 | 9/20 | 0.46 |
| ▸ | TAOK1 | Q7L7X3 | 8/20 | 0.46 |
| ▸ | CSNK1G3 | Q9Y6M4 | 8/20 | 0.46 |
| ▸ | GSK3B | P49841 | 8/20 | 0.46 |
| ▸ | CSNK1G2 | P78368 | 7/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.46 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.46 |
| ▸ | FRK | P42685 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3520464 | 0.85 | CDK2 (0.67) | CDK2CSNK1ECCNA2CDK5CDK5R1 | |
| SCHEMBL3525735 | 0.82 | MAPK9 (0.63) | CDK2CSNK1ECCNA2CDK5CDK5R1 | |
| SCHEMBL4300868 | 0.80 | MAP4K4 (0.55) | CDK2CSNK1ECCNA2CDK5CDK5R1 | |
| SCHEMBL4923880 | 0.80 | MAPK9 (0.67) | CDK2CSNK1ECCNA2CDK5CDK5R1 | |
| SCHEMBL3663945 | 0.76 | MAPK9 (0.68) | CDK2CSNK1ECCNA2CDK5CDK5R1 | |
| SCHEMBL3520110 | 0.75 | CSNK1E (0.48) | CDK2CSNK1ECCNA2CDK5CDK5R1 | |
| SCHEMBL3528432 | 0.69 | CSNK1E (0.59) | CDK2CSNK1ECCNA2CDK5CDK5R1 | |
| SCHEMBL4471008 | 0.69 | MAPK14 (0.60) | CDK2CSNK1ECCNA2CDK5CDK5R1 | |
| SCHEMBL13920968 | 0.69 | MAPK14 (0.60) | CDK2CSNK1ECCNA2CDK5CDK5R1 | |
| SCHEMBL3522644 | 0.68 | PRKD3 (0.62) | CDK2CSNK1ECCNA2CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709468-B2 | Imidazo based heterocycles | ABBOTT LABORATORIES (US) | 2010-05-04 | — | — | US | disclosed |
| US-7709468-B2 | Imidazo based heterocycles | ABBOTT LABORATORIES (US) | 2010-05-04 | — | — | US | disclosed |
| US-7709468-B2 | Imidazo based heterocycles | ABBOTT LABORATORIES (US) | 2010-05-04 | — | — | US | disclosed |
| US-20070099925-A1 | Novel imidazo based heterocycles | ABBVIE INC. | 2007-05-03 | — | — | US | disclosed |
| US-20070099925-A1 | Novel imidazo based heterocycles | ABBVIE INC. | 2007-05-03 | — | — | US | disclosed |
| US-20070099925-A1 | Novel imidazo based heterocycles | ABBVIE INC. | 2007-05-03 | — | — | US | disclosed |
| WO-2007028051-A2 | NOVEL IMIDAZO BASED HETEROCYCLES | ABBOTT LABORATORIES (US) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099925-A1 | Novel imidazo based heterocycles | CDK4, CDK2, MAP3K19 | CDK2 2/4885CSNK1E 216/4885CCNA2 208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.