Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 4/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14561099 | 0.88 | MAPK14 (0.49) | CSNK1EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5410735 | 0.82 | MAPK14 (0.54) | CSNK1EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3520464 | 0.81 | CDK2 (0.67) | CSNK1EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6214225 | 0.80 | MAPK14 (0.73) | CSNK1EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL11467792 | 0.77 | LMNA (0.58) | MAPK14CDK2CCNA2CDK5CDK5R1 | |
| SCHEMBL7676136 | 0.77 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11CDK2 | |
| SCHEMBL3522704 | 0.75 | CDK2 (0.49) | CSNK1EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL14561096 | 0.74 | MAPK14 (0.47) | CSNK1EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5813593 | 0.72 | MAPK14 (0.46) | MAPK14CDK2CCNA2CDK5CDK5R1 | |
| SCHEMBL7222330 | 0.72 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709468-B2 | Imidazo based heterocycles | ABBOTT LABORATORIES (US) | 2010-05-04 | — | — | US | disclosed |
| US-7709468-B2 | Imidazo based heterocycles | ABBOTT LABORATORIES (US) | 2010-05-04 | — | — | US | disclosed |
| US-7709468-B2 | Imidazo based heterocycles | ABBOTT LABORATORIES (US) | 2010-05-04 | — | — | US | disclosed |
| US-20070099925-A1 | Novel imidazo based heterocycles | ABBVIE INC. | 2007-05-03 | — | — | US | disclosed |
| US-20070099925-A1 | Novel imidazo based heterocycles | ABBVIE INC. | 2007-05-03 | — | — | US | disclosed |
| US-20070099925-A1 | Novel imidazo based heterocycles | ABBVIE INC. | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099925-A1 | Novel imidazo based heterocycles | CDK4, CDK2, MAP3K19 | CSNK1E 216/4885MAPK14 66/4885MAPK13 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.