Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 9/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | NT5E | P21589 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | GLI1 | P08151 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.56 |
| ▸ | ALB | P02768 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.56 |
| ▸ | RORC | P51449 | 1/20 | 0.56 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.56 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13351911 | 1.00 | GPBAR1 (0.64) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| SCHEMBL14398790 | 1.00 | GPBAR1 (0.64) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| SCHEMBL5442215 | 1.00 | GPBAR1 (0.64) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| SCHEMBL3526193 | 0.92 | GPBAR1 (0.54) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| Lupane Anhydride SCHEMBL2133330 | 0.92 | GPBAR1 (0.54) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| SCHEMBL13351877 | 0.92 | GPBAR1 (0.54) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| Lupane Anhydride SCHEMBL2141349 | 0.92 | GPBAR1 (0.54) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| SCHEMBL13351982 | 0.92 | GPBAR1 (0.54) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| Lupane Anhydride SCHEMBL3525136 | 0.92 | GPBAR1 (0.54) | GPBAR1LMNANT5ESMN1; SMN2GLI1 | |
| Lupane Anhydride SCHEMBL2135129 | 0.92 | GPBAR1 (0.54) | GPBAR1LMNANT5ESMN1; SMN2GLI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101149-A1 | Betulinic Acid Derivatives and Methods of Use Thereof | REATA PHARMACEUTICALS, INC. | 2012-04-26 | — | — | US | disclosed |
| WO-2010053817-A1 | BETULINIC ACID DERIVATIVES AND METHODS OF USE THEREOF | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101149-A1 | Betulinic Acid Derivatives and Methods of Use Thereof | BET1, PGGT1B, CYP3A5 | GPBAR1 75/4885LMNA 1890/4885NT5E 591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.