SCHEMBL35252

SCHEMBL35252

[c]1ncc2cccnc2n1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.38
KDM4E B2RXH2 2/20 0.38
MMP2 P08253 2/20 0.38
TSHR P16473 2/20 0.38
CCR1 P32246 2/20 0.38
CCR5 P51681 2/20 0.38
CCR8 P51685 2/20 0.38
CYP3A4 P08684 2/20 0.38
GMNN O75496 1/20 0.38
TP53 P04637 1/20 0.38
HSP90AA1 P07900 1/20 0.38
CYP2D6 P10635 1/20 0.38
MAPT P10636 1/20 0.38
MMP9 P14780 1/20 0.38
ALOX15 P16050 1/20 0.38
NFKB1 P19838 1/20 0.38
MMP8 P22894 1/20 0.38
THPO P40225 1/20 0.38
MTOR P42345 1/20 0.38
HTT P42858 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4416476 0.73 NPC1 (0.44) KDM4ETSHRTP53HSP90AA1MAPT
SCHEMBL4751394 0.72 NPC1 (0.43) KDM4ETSHRTP53HSP90AA1MAPT
SCHEMBL3936511 0.71
SCHEMBL8193 0.69 CCR1 (0.55) LMNAKDM4EMMP2TSHRCCR1
SCHEMBL28304525 0.69 CCR1 (0.55) LMNAKDM4EMMP2TSHRCCR1
SCHEMBL29354893 0.69 CCR1 (0.55) LMNAKDM4EMMP2TSHRCCR1
SCHEMBL159794 0.68 EGFR (0.34)
SCHEMBL153747 0.68 ALDH1A1 (0.43) LMNAKDM4ETSHRCYP3A4TP53
SCHEMBL15892 0.68 ALDH1A1 (0.41) LMNAKDM4EMMP2TSHRCCR1
SCHEMBL6710807 0.68 ALDH1A1 (0.52) LMNAKDM4EMAPTTDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2185 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230382905-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY EVOTEC INTERNATIONAL GMBH (DE) 2023-11-30 US claimed
US-20230357268-A1 PREPARATION AND APPLICATION OF TRICYCLIC PYRIMIDINONE COMPOUND AND ITS COMPOSITION NEUSCO BIOTECH LIMITED (CN) 2023-11-09 US claimed
US-20230271980-A1 PREPARATION AND APPLICATION OF TRICYCLIC PYRIMIDINONE COMPOUND AND ITS COMPOSITION NEUSCO BIOTECH LIMITED (CN) 2023-08-31 US claimed
EP-4232154-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY Evotec International GmbH (DE) 2023-08-30 EP claimed
US-20230242532-A1 TETRACYCLIC PYRIMIDINONE COMPOUND, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF NEUSCO BIOTECH LIMITED (CN) 2023-08-03 US claimed
US-20230212168-A1 ENDOCYCLIC PYRIMIDINONE COMPOUNDS, AND PREPARATION METHODS, COMPOSITIONS AND USE THEREOF NEUSCO BIOTECH LIMITED (CN) 2023-07-06 US claimed
EP-4180436-A1 TRICYCLIC PYRIMIDINONE COMPOUND, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF Neusco Biotech Limited (CN) 2023-05-17 EP claimed
EP-4174070-A1 TRICYCLIC PYRIMIDINONE COMPOUND, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF Neusco Biotech Limited (CN) 2023-05-03 EP claimed
EP-4151638-A1 BRIDGED CYCLIC PYRIMIDINONE COMPOUND, PREPARATION METHOD THEREFOR, COMPOSITION CONTAINING SAME AND USE THEREOF Neusco Biotech Limited (CN) 2023-03-22 EP claimed
WO-2022084448-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY EVOTEC INTERNATIONAL GMBH (DE) 2022-04-28 WO claimed
US-4822790-A ANTIMICROBIOCIDES OR BETA-LACTAMASE INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1989-04-18 US claimed
US-4801703-A PHOSPHORUS COMPOUNDS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1989-01-31 US claimed
US-4788185-A Cephalosporin compounds TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1988-11-29 US claimed
US-4751299-A Optically active β-lactams and method of their production TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1988-06-14 US claimed
EP-0053816-B1 1-SULFO-2-OXOAZETIDINE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1988-05-04 EP claimed
US-4684724-A ANTIBIOTICS, BETA-LACTAMASE INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1987-08-04 US claimed
US-4675397-A MICROBIOCIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1987-06-23 US claimed
US-4665067-A BACTERICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1987-05-12 US claimed
US-4560508-A BETA-LACTAMASE INHIBITORS, ANINICROBIAL AGENT, CHEMICAL INTERMEDIATE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1985-12-24 US claimed
US-4550105-A BETA-LACTAMASE INHIBITORS, ANTIBIOTICS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1985-10-29 US claimed