Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.39 |
| ▸ | LTK | P29376 | 2/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | MST1R | Q04912 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3527492 | 0.76 | PDE3B (0.48) | PDE3BPDE3ALRRK2LTKALK | |
| SCHEMBL16447534 | 0.74 | PDE3B (0.51) | PDE3BPDE3ALRRK2LTKALK | |
| SCHEMBL3523063 | 0.74 | PDE5A (0.47) | GSK3AGSK3BCCNE1CDK2 | |
| SCHEMBL3524484 | 0.74 | PDE5A (0.33) | LRRK2LTKALKDYRK1BRET | |
| SCHEMBL5548540 | 0.71 | PDE5A (0.32) | GSK3AGSK3B | |
| SCHEMBL3523002 | 0.71 | HCAR2 (0.34) | LRRK2LTKALKDYRK1BRET | |
| SCHEMBL17796160 | 0.70 | PDE3B (0.51) | PDE3BPDE3ALRRK2LTKALK | |
| SCHEMBL3527613 | 0.70 | PDE3B (0.48) | PDE3BPDE3ALRRK2LTKALK | |
| SCHEMBL3524745 | 0.69 | SYK (0.39) | GSK3AGSK3B | |
| SCHEMBL3523302 | 0.69 | CCNE1 (0.36) | PDE3BPDE3ATTKCCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709473-B2 | Substituted 2H-[1,2,4]triazolo[4,3-a]pyrazines as GSK-3 inhibitors | PFIZER INC. (US) | 2010-05-04 | — | — | US | disclosed |
| US-20070249612-A1 | Substituted 2H-[1,2,4]Triazolo[4,3-A]Pyrazines as Gsk-3 Inhibitors | BENBOW JOHN W | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249612-A1 | Substituted 2H-[1,2,4]Triazolo[4,3-A]Pyrazines as Gsk-3 Inhibitors | GSK3B, GSK3A, GSKIP | PDE3B 795/4885PDE3A 599/4885FLT3 316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.