Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3522851 | 0.86 | CXCR2 (0.35) | — | |
| SCHEMBL5548896 | 0.85 | GRK6 (0.34) | — | |
| SCHEMBL5550127 | 0.84 | CYP3A4 (0.37) | PDE5AKDM4EMAPT | |
| SCHEMBL5549359 | 0.84 | LPAR2 (0.31) | — | |
| SCHEMBL5548550 | 0.82 | NTRK1 (0.39) | PDE5A | |
| SCHEMBL5548899 | 0.81 | GSK3B (0.32) | GSK3AGSK3B | |
| SCHEMBL5548901 | 0.81 | SLC6A4 (0.38) | PDE5AKDM4ENPC1MAPTRAB9A | |
| SCHEMBL3524484 | 0.81 | PDE5A (0.33) | PDE5ABTKGSK3AGSK3B | |
| SCHEMBL3523063 | 0.81 | PDE5A (0.47) | PDE5ABTKGSK3AGSK3B | |
| SCHEMBL5545643 | 0.80 | GSK3B (0.34) | PDE5AGSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |