Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 6/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.41 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3527813 | 0.83 | EGFR (0.47) | BRAFEGFRCYP3A4JAK3MAPK10 | |
| SCHEMBL3519701 | 0.79 | MAPK9 (0.58) | EGFRMAPK9CSNK1DPRKD2MAPK8 | |
| SCHEMBL3529133 | 0.75 | BRAF (0.47) | BRAFEGFRCYP3A4JAK3MAPK10 | |
| SCHEMBL3525985 | 0.74 | MAPK9 (0.62) | EGFRMAPK9CSNK1DPRKD2MAPK8 | |
| SCHEMBL14561140 | 0.74 | BRAF (0.46) | BRAFEGFRCYP3A4JAK3MAPK10 | |
| SCHEMBL3522329 | 0.72 | MAPK9 (0.48) | BRAFEGFRCYP3A4JAK3MAPK10 | |
| SCHEMBL12023947 | 0.72 | BRAF (0.78) | BRAFEGFRCYP3A4JAK3MAPK10 | |
| SCHEMBL5410747 | 0.70 | BRAF (0.48) | BRAFEGFRCYP3A4JAK3MAPK10 | |
| SCHEMBL14561100 | 0.70 | BRAF (0.50) | BRAFEGFRCYP3A4JAK3MAPK10 | |
| SCHEMBL3522612 | 0.70 | MAPK9 (0.58) | MAPK9CSNK1DPRKD2MAPK8CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709468-B2 | Imidazo based heterocycles | ABBOTT LABORATORIES (US) | 2010-05-04 | — | — | US | disclosed |
| EP-1928237-A2 | NOVEL IMIDAZO BASED HETEROCYCLES | Abbott Laboratories (US) | 2008-06-11 | — | — | EP | disclosed |
| US-20070099925-A1 | Novel imidazo based heterocycles | ABBVIE INC. | 2007-05-03 | — | — | US | disclosed |
| WO-2007028051-A2 | NOVEL IMIDAZO BASED HETEROCYCLES | ABBOTT LABORATORIES (US) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099925-A1 | Novel imidazo based heterocycles | CDK4, CDK2, MAP3K19 | BRAF 49/4885EGFR 785/4885CYP3A4 1020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.