Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.42 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3527813 | 0.89 | EGFR (0.47) | BRAFEGFRCYP3A4JAK3MAPK10 | |
| SCHEMBL3522329 | 0.86 | MAPK9 (0.48) | BRAFEGFRCYP3A4JAK3MAPK10 | |
| SCHEMBL3525318 | 0.78 | MAPK9 (0.61) | EGFRCSNK1EPRKD3MAP4K4MAPK8 | |
| SCHEMBL3526366 | 0.75 | BRAF (0.51) | BRAFEGFRCYP3A4JAK3MAPK10 | |
| SCHEMBL3522612 | 0.73 | MAPK9 (0.58) | CSNK1EPRKD3MAP4K4MAPK8MAPK9 | |
| SCHEMBL3525223 | 0.73 | GRIA1 (0.55) | CSNK1EPRKD3MAP4K4MAPK8MAPK9 | |
| SCHEMBL12023947 | 0.71 | BRAF (0.78) | BRAFEGFRCYP3A4JAK3MAPK10 | |
| SCHEMBL3519701 | 0.70 | MAPK9 (0.58) | EGFRCSNK1EPRKD3MAP4K4MAPK8 | |
| SCHEMBL14561140 | 0.70 | BRAF (0.46) | BRAFEGFRCYP3A4JAK3MAPK10 | |
| SCHEMBL3523791 | 0.69 | MAPK9 (0.51) | BRAFEGFRCYP3A4JAK3MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709468-B2 | Imidazo based heterocycles | ABBOTT LABORATORIES (US) | 2010-05-04 | — | — | US | disclosed |
| EP-1928237-A2 | NOVEL IMIDAZO BASED HETEROCYCLES | Abbott Laboratories (US) | 2008-06-11 | — | — | EP | disclosed |
| US-20070099925-A1 | Novel imidazo based heterocycles | ABBVIE INC. | 2007-05-03 | — | — | US | disclosed |
| WO-2007028051-A2 | NOVEL IMIDAZO BASED HETEROCYCLES | ABBOTT LABORATORIES (US) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099925-A1 | Novel imidazo based heterocycles | CDK4, CDK2, MAP3K19 | BRAF 49/4885EGFR 785/4885CYP3A4 1020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.