Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.41 |
| ▸ | GLRB | P48167 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.38 |
| ▸ | TUBB | P07437 | 5/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.38 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3521880 | 0.75 | ALDH1A1 (0.39) | MAPK8MAPK9MAPK10HTTALOX15 | |
| SCHEMBL3521595 | 0.75 | MAPT (0.37) | MAPK8MAPK9MAPK10HTTALOX15 | |
| SCHEMBL3518477 | 0.75 | MAPK8 (0.37) | TUBB1MAPK8MAPK9MAPK10HTT | |
| SCHEMBL3524985 | 0.73 | EGLN3 (0.40) | CFTREGLN3 | |
| SCHEMBL3520012 | 0.73 | MAPK8 (0.35) | MAPK8MAPK9MAPK10HTTALOX15 | |
| SCHEMBL3520015 | 0.71 | MAPK8 (0.39) | MAPK8MAPK9MAPK10HTTALOX15 | |
| SCHEMBL3536799 | 0.68 | EGLN3 (0.62) | EGLN3 | |
| SCHEMBL305696 | 0.65 | CFTR (0.53) | CFTRGLRA3GLRBLMNA | |
| SCHEMBL16463175 | 0.65 | CYP46A1 (0.58) | CFTRGLRA3GLRBTUBB4ATUBB | |
| SCHEMBL28466606 | 0.65 | GLRA3 (0.47) | CFTRGLRA3GLRBTUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305133-A1 | Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2010-12-02 | — | — | US | disclosed |
| EP-2227770-A2 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073497-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305133-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN3, EGLN2 | CFTR 3312/4885GLRA3 2144/4885GLRB 1901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.