⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2577858 | 0.81 | — | — | |
| SCHEMBL28241299 | 0.81 | — | — | |
| SCHEMBL6762286 | 0.81 | — | — | |
| SCHEMBL1167332 | 0.81 | — | — | |
| SCHEMBL9586018 | 0.79 | SMN1; SMN2 (0.44) | — | |
| SCHEMBL692747 | 0.78 | KDM4E (0.38) | — | |
| SCHEMBL2263002 | 0.78 | LMNA (0.34) | — | |
| SCHEMBL27817045 | 0.78 | TSHR (0.59) | — | |
| SCHEMBL128090 | 0.76 | NR1I2 (0.31) | — | |
| SCHEMBL28902605 | 0.76 | TSHR (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 212 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200440-B1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | CRESTONE INC (US) | 2017-07-19 | — | — | EP | claimed |
| US-8148380-B2 | Antibacterial amide and sulfonamide substituted heterocyclic urea compounds | CRESTONE, INC. (US) | 2012-04-03 | — | — | US | claimed |
| US-20120015941-A1 | Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds | CRESTONE, INC. (US) | 2012-01-19 | — | — | US | claimed |
| EP-2200440-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | Crestone, Inc. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009015208-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | REPLIDYNE, INC. (US) | 2009-01-29 | — | — | WO | claimed |
| CN-100347169-C | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-11-07 | — | — | CN | claimed |
| CN-1471527-A | Quinazoline derivatives | — | 2004-01-28 | — | — | CN | claimed |
| EP-1218739-A4 | 2-AMINOPYRIDINE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2003-06-04 | — | — | EP | claimed |
| EP-1218739-A1 | 2-AMINOPYRIDINE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2002-07-03 | — | — | EP | claimed |
| US-6339087-B1 | FOR THERAPY OF INFLAMMATORY OR ALLERGIC DISEASES ARE SELECTED FROM ASTHMA, ALLERGIC RHINITIS, HYPERSENSITIVITY LUNG DISEASES, HYPERSENSITIVITY PNEUMONITIS, EOSINOPHILIC PNEUMONIAS, INFLAMMATORY BOWEL DISEASES, PSORIASIS, DERMATITIS | SYNTEX (U.S.A.) LLC | 2002-01-15 | — | — | US | claimed |
| WO-2001023887-A1 | 2-AMINOPYRIDINE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-04-05 | — | — | WO | claimed |
| CN-1252070-A | 5,7-disubstituted 4-aminopyrido [2,3,-d] pyrimidine compounds and their use as adenosine kinase inhibitors | ABBOTT LAB (US) | 2000-05-03 | — | — | CN | claimed |
| CN-1252069-A | 5,6, 7-trisubstituted-4-aminopyrido [2, 3-d ] pyrimidine compounds | ABBOTT LAB (US) | 2000-05-03 | — | — | CN | claimed |
| CN-1171394-A | New urea derivatives, their preparation and their therapeutic and prophylactic use | SANKYO CO (JP) | 1998-01-28 | — | — | CN | claimed |
| US-5703108-A | Bone deposition by certain prostaglandin agonists | PFIZER INC. (US) | 1997-12-30 | — | — | US | claimed |
| CN-1100262-A | New herbicides | RHONE POULENC AGRICULTURE (GB) | 1995-03-22 | — | — | CN | claimed |
| US-5290536-A | Phenyl substituted 2-thiazolyl tetrazolium salt indicators | MILES INC. (US) | 1994-03-01 | — | — | US | claimed |
| US-4619943-A | NEUROLEPTIC AGENTS | RAO KOPPAKA V | 1986-10-28 | — | — | US | claimed |
| EP-0065165-A1 | 5-Oxymethyl-4-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-24 | — | — | EP | claimed |
| CN-114005980-B | Negative electrode material and lithium ion battery containing same | 珠海冠宇电池股份有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-108779093-A | N1- (tri- fluoro- 2- hydroxy-2-methyls propionos of 3,3,3-)-piperidine derivative of inhibitor as pyruvic dehydrogenase kinase | 默克专利股份公司 | 2018-11-09 | — | — | CN | disclosed |
| EP-2200440-B1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | CRESTONE INC (US) | 2017-07-19 | — | — | EP | disclosed |
| CN-102731382-B | 6-(polysubstituted aryl)-4-aminopyridine manthanoate and the purposes as weedicide thereof | THE DOW AGROSCIENCES, LLC. (US) | 2015-09-02 | — | — | CN | disclosed |
| CN-102272125-B | Pyridazinone derivatives | MERCK PATENT GMBH | 2014-01-08 | — | — | CN | disclosed |
| CN-101743241-B | Pyridazinone derivates | MERCK PATENT GMBH | 2013-12-25 | — | — | CN | disclosed |
| CN-101952287-B | Protein kinase inhibitors and use thereof | MERCK SERONO SA | 2013-11-27 | — | — | CN | disclosed |
| CN-103370331-A | Amino statin derivatives for the treatment of arthrosis | MERCK PATENT GMBH | 2013-10-23 | — | — | CN | disclosed |
| CN-102046605-B | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors | MERCK PATENT GMBH | 2013-09-18 | — | — | CN | disclosed |
| CN-101501028-B | 2- (heterocyclylbenzyl) pyridazinone derivatives | MERCK PATENT GMBH | 2013-09-11 | — | — | CN | disclosed |
| CN-101743229-B | Quinazolinamide derivatives | MERCK PATENT GMBH | 2013-08-14 | — | — | CN | disclosed |
| CN-103228657-A | 3-heteroaryl-substituted pyrrolo [2,3-b ] pyridine derivatives as PDK1 inhibitors | MERCK PATENT GMBH | 2013-07-31 | — | — | CN | disclosed |
| CN-101072758-B | Quinazoline derivatives | ASTRAZENECA AB | 2013-07-31 | — | — | CN | disclosed |
| CN-103119037-A | Phenyl quinazoline derivatives | MERCK PATENT GMBH | 2013-05-22 | — | — | CN | disclosed |
| CN-103080092-A | Pyrazolo-quinolines | MERCK PATENT GMBH | 2013-05-01 | — | — | CN | disclosed |
| CN-103068803-A | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | MERCK PATENT GMBH | 2013-04-24 | — | — | CN | disclosed |
| WO-2013047904-A1 | AMIDE COMPOUND AND USE THEREOF FOR CONTROLLING HARMFUL ARTHROPODS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-04-04 | — | — | WO | disclosed |
| CN-102977036-A | 2-(poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides | DOW AGROSCIENCES LLC | 2013-03-20 | — | — | CN | disclosed |
| CN-102906199-A | Polymer-bound perylene dyes and compositions containing the same | SICPA HOLDING SA | 2013-01-30 | — | — | CN | disclosed |
| CN-101809001-B | Imidazole derivatives | MERCK PATENT GMBH | 2012-12-12 | — | — | CN | disclosed |
| CN-101679401-B | 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as MET kinase inhibitors for the treatment of tumors | MERCK PATENT GMBH | 2012-12-12 | — | — | CN | disclosed |
| CN-102822171-A | Benzonaphthyridinamines as autotaxin inhibitors | MERCK PATENT GMBH | 2012-12-12 | — | — | CN | disclosed |
| CN-102123710-B | Bicyclic triazole derivatives for treating tumors | MERCK PATENT GMBH | 2012-11-07 | — | — | CN | disclosed |
| US-8288560-B2 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | IPSEN PHARMA S.A.S. (FR) | 2012-10-16 | — | — | US | disclosed |
| CN-102712636-A | Compounds and compositions as TLR activity modulators | IRM LLC | 2012-10-03 | — | — | CN | disclosed |
| CN-102666509-A | Thiazole derivatives for treating diseases such as cancer | MERCK PATENT GMBH | 2012-09-12 | — | — | CN | disclosed |
| CN-102666489-A | Sphingosine kinase inhibitors | MERCK PATENT GMBH | 2012-09-12 | — | — | CN | disclosed |
| CN-101374843-B | Triazolopyridazines as tyrosine kinase modulators | JANSSEN PHARMACEUTICA NV | 2012-09-05 | — | — | CN | disclosed |
| CN-102648178-A | Quinazoline derivatives | MERCK PATENT GMBH | 2012-08-22 | — | — | CN | disclosed |
| CN-101184751-B | Quinazolines and their use as AURORA kinase inhibitors | ASTRAZENECA AB | 2012-08-15 | — | — | CN | disclosed |
| US-8148380-B2 | Antibacterial amide and sulfonamide substituted heterocyclic urea compounds | CRESTONE, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| CN-101115744-B | Process for preparing 4- (6-chloro-2, 3-methylenedioxyanilino) -7- [2- (4-methylpiperazin-1-yl) ethoxy ] -5-tetrahydropyran-4-yloxyquinazoline, intermediates and crystalline salts thereof | ASTRAZENECA AB (SE) | 2012-02-01 | — | — | CN | disclosed |
| US-20120015941-A1 | Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds | CRESTONE, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| CN-101312725-B | hexahydro-cyclooctyl pyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA NV | 2012-01-11 | — | — | CN | disclosed |
| CN-102272131-A | Pyridazinone derivatives | — | 2011-12-07 | — | — | CN | disclosed |
| CN-102272125-A | Pyridazinone derivatives | — | 2011-12-07 | — | — | CN | disclosed |
| CN-102264727-A | Pyridazinone derivatives | — | 2011-11-30 | — | — | CN | disclosed |
| CN-102264742-A | 3-(3-pyrimidine-2-yl-benzyl)-[1,2,4] triazolo [4,3-b] pyridazine derivatives | — | 2011-11-30 | — | — | CN | disclosed |
| CN-102256980-A | 3- (3-pyrimidin-2-ylbenzyl) -1,2, 4-triazolo [4,3-b ] pyrimidine derivatives | MERCK PATENT GMBH | 2011-11-23 | — | — | CN | disclosed |
| CN-102149379-A | Methods of modulating hepatocyte growth factor (scatter factor) activity and small molecule modulator compositions of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP | 2011-08-10 | — | — | CN | disclosed |
| US-20110172434-A1 | DERIVATIVES OF HETEROCYCLES WITH 5 MEMBERS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | IPSEN PHARMA S.A.S. (FR) | 2011-07-14 | — | — | US | disclosed |
| CN-102123710-A | Bicyclic triazole derivatives for treating tumors | MERCK PATENT GMBH | 2011-07-13 | — | — | CN | disclosed |
| CN-1956964-B | Tetrahydro-indazole cannabinoid modulators | JANSSEN PHARMACEUTICA NV | 2011-06-15 | — | — | CN | disclosed |
| US-7956075-B2 | Thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives, e.g., butyl 2-(4-[1,1'-biphenyl]-4-yl-1H-imidazol-2-yl)ethylcarbamate inhibit lipidic peroxidation and monoamine oxidase and modulate sodium channels and are used for treating neurodegenerative disorders or pain. | IPSEN PHARMA S.A.S. (FR) | 2011-06-07 | — | — | US | disclosed |
| CN-102046605-A | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors | MERCK PATENT GMBH | 2011-05-04 | — | — | CN | disclosed |
| CN-102015694-A | Pyridazinone derivatives | MERCK PATENT GMBH | 2011-04-13 | — | — | CN | disclosed |
| CN-101326167-B | Pyridiazinone derivatives for tumour treatment | MERCK PATENT GMBH | 2011-03-09 | — | — | CN | disclosed |
| CN-101952287-A | Kinases inhibitor and application thereof | MERCK SERONO SA | 2011-01-19 | — | — | CN | disclosed |
| CN-101918404-A | 4-(pyrrolo[2,3-c]pyridine-3-yl)-pyrimidine-2-amine derivatives | MERCK PATENT GMBH | 2010-12-15 | — | — | CN | disclosed |
| CN-101910129-A | Synthesis of quaternary salt compounds | JANSSEN PHARMACEUTICA NV | 2010-12-08 | — | — | CN | disclosed |
| CN-101903374-A | 2-benzylpyridazinone derivatives as met kinase inhibitors | MERCK PATENT GMBH | 2010-12-01 | — | — | CN | disclosed |
| CN-101815714-A | Thiazol derivatives | MERCK PATENT GMBH | 2010-08-25 | — | — | CN | disclosed |
| CN-101809001-A | Imdazole derivatives | MERCK PATENT GMBH | 2010-08-18 | — | — | CN | disclosed |
| CN-101790519-A | 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (s1p) receptor for the treatment of multiple sclerosis | SERONO LAB | 2010-07-28 | — | — | CN | disclosed |
| CN-101790513-A | 1,3-dihydroisoindole derivatives | MERCK PATENT GMBH | 2010-07-28 | — | — | CN | disclosed |
| EP-2200440-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | Crestone, Inc. (US) | 2010-06-30 | — | — | EP | disclosed |
| CN-101743229-A | quinazolinamide derivatives | MERCK PATENT GMBH | 2010-06-16 | — | — | CN | disclosed |
| CN-101743241-A | pyridazinone derivates | MERCK PATENT GMBH | 2010-06-16 | — | — | CN | disclosed |
| CN-1537000-B | Novel imidazolidine derivatives, their preparation and their use as VLA-4 antagonists | AVENTIS PHARMA GMBH | 2010-05-12 | — | — | CN | disclosed |
| CN-101687808-A | indazolamide derivatives | MERCK PATENT GMBH | 2010-03-31 | — | — | CN | disclosed |
| CN-101679303-A | pyridazinone derivatives | MERCK PATENT GMBH | 2010-03-24 | — | — | CN | disclosed |
| CN-101679401-A | 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as MET kinase inhibitors for the treatment of tumors | MERCK PATENT GMBH | 2010-03-24 | — | — | CN | disclosed |
| CN-101677985-A | Six hydrogen-cycloocta pyrazoles cannabinoid modulators | JANSSEN PHARMACEUTICA NV | 2010-03-24 | — | — | CN | disclosed |
| CN-101677555-A | Methods of treating CB2 receptor mediated pain | JANSSEN PHARMACEUTICA NV | 2010-03-24 | — | — | CN | disclosed |
| CN-101677557-A | Six hydrogen-cycloheptatriene and pyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA NV | 2010-03-24 | — | — | CN | disclosed |
| CN-101678214-A | aryl ether pyridazinone derivatives | MERCK PATENT GMBH | 2010-03-24 | — | — | CN | disclosed |
| CN-101616918-A | 4- (pyrrolopyridinyl) pyrimidin-2-ylamine derivatives | MERCK PATENT GMBH | 2009-12-30 | — | — | CN | disclosed |
| CN-100526290-C | Method for the enantioselective hydrogenation of amino alcohols | MERCK PATENT GMBH (DE) | 2009-08-12 | — | — | CN | disclosed |
| CN-101500560-A | Tetrahydropyridylpyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2009-08-05 | — | — | CN | disclosed |
| CN-101501028-A | 2- (heterocyclylbenzyl) pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2009-08-05 | — | — | CN | disclosed |
| CN-101489551-A | Aminoindazole urea derivatives | MERCK PATENT GMBH (DE) | 2009-07-22 | — | — | CN | disclosed |
| CN-101484425-A | Indazole derivatives for treating HSP90-induced diseases | MERCK PATENT GMBH (DE) | 2009-07-15 | — | — | CN | disclosed |
| CN-100497345-C | 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |
| CN-101443316-A | 1,5-diphenylpyrazoles II as HSP90 inhibitors | MERCK PATENT GMBH (DE) | 2009-05-27 | — | — | CN | disclosed |
| CN-101443003-A | Triazole derivatives II | MERCK PATENT GMBH (DE) | 2009-05-27 | — | — | CN | disclosed |
| CN-101437811-A | Quinoline derivatives | ASTRAZENECA AB (SE) | 2009-05-20 | — | — | CN | disclosed |
| CN-101437812-A | Quinoline derivatives for the treatment of cancer | ASTRAZENECA AB (SE) | 2009-05-20 | — | — | CN | disclosed |
| CN-101433717-A | Drugs containing chymase inhibitor and ACE inhibitor as the active ingredients | TEIJIN LTD (JP) | 2009-05-20 | — | — | CN | disclosed |
| CN-101432276-A | Quinoline derivatives | ASTRAZENECA AB (SE) | 2009-05-13 | — | — | CN | disclosed |
| EP-1506175-B1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-01 | — | — | EP | disclosed |
| CN-101374843-A | Triazolopyridazines as tyrosine kinase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-25 | — | — | CN | disclosed |
| WO-2009015208-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | REPLIDYNE, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
| CN-101341151-A | Diazepinones | MERCK PATENT GMBH (DE) | 2009-01-07 | — | — | CN | disclosed |
| CN-101326167-A | Pyridiazinone derivatives for tumour treatment | MERCK PATENT GMBH (DE) | 2008-12-17 | — | — | CN | disclosed |
| CN-101312725-A | Hexahydro-cyclooctyl pyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-26 | — | — | CN | disclosed |
| CN-101312724-A | Tetrahydro-indazolyl cannabinoid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-26 | — | — | CN | disclosed |
| CN-101312956-A | Substituted 5-phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazines | MERCK PATENT GMBH (DE) | 2008-11-26 | — | — | CN | disclosed |
| CN-101312726-A | Hexahydro cyclooctyl pyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-26 | — | — | CN | disclosed |
| CN-101300249-A | Aminoquinoline and aminoquinazoline kinase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-05 | — | — | CN | disclosed |
| CN-101255170-A | 2,3-dihydroimidazo[2,1-b]oxazole compound | OTSUKA PHARMA CO LTD (JP) | 2008-09-03 | — | — | CN | disclosed |
| CN-101242837-A | Synergistic modulation of FLT3 kinase with aminopyrimidine kinase modulators and farnesyl transferase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-13 | — | — | CN | disclosed |
| CN-101242843-A | Aminopyrimidines as kinase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-13 | — | — | CN | disclosed |
| CN-101242844-A | Aminopyrimidines as kinase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-13 | — | — | CN | disclosed |
| CN-101243048-A | 1-acyldihydropyrazol derivatives | MERCK PATENT GMBH (DE) | 2008-08-13 | — | — | CN | disclosed |
| CN-101242846-A | Synergistic modulation of FLT3 kinase using thienopyrimidine and thienopyridine kinase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-13 | — | — | CN | disclosed |
| CN-101242847-A | Synergistic modulation of FLT3 kinase using aminopyrimidines kinase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-13 | — | — | CN | disclosed |
| CN-101242838-A | Synergistic modulation of FLT3 kinase using aminoquinoline and aminoquinazoline kinase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-13 | — | — | CN | disclosed |
| CN-101242845-A | Synergistic modulation of FLT3 kinase using a farnesyl transferase inhibitor | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-13 | — | — | CN | disclosed |
| CN-100396670-C | N-substituted 3-aminobenzene-pyrazoles as PDFG receptor inhibitors, pharmaceutical compositions and uses | JANSSEN PHARMACEUTICA NV (BE) | 2008-06-25 | — | — | CN | disclosed |
| US-20080146627-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | LASSAUNIERE PIERRE-ETIENNE CHA | 2008-06-19 | — | — | US | disclosed |
| CN-101180278-A | 2-amino-4-phenylquinazoline derivates and their use as HSP90 modulators | MERCK PATENT GMBH (DE) | 2008-05-14 | — | — | CN | disclosed |
| CN-101172981-A | 2,3-dihydroimidazo[2,1-b]oxazole compound | OTSUKA PHARMA CO LTD (JP) | 2008-05-07 | — | — | CN | disclosed |
| CN-101163707-A | Thienopyridines | MERCK PATENT GMBH (DE) | 2008-04-16 | — | — | CN | disclosed |
| CN-101146766-A | Acyl hydrazides as kinase inhibitors, in particular for SGK | MERCK PATENT GMBH (DE) | 2008-03-19 | — | — | CN | disclosed |
| EP-1893214-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING ALKYLQUINOLINES AND ALKYLQUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-05 | — | — | EP | disclosed |
| CN-100366624-C | 2, 3-dihydro-6-nitroimidazo [2,1-b ] * azole compounds | OTSUKA PHARMA CO LTD (JP) | 2008-02-06 | — | — | CN | disclosed |
| CN-101115744-A | Process for preparing 4- (6-chloro-2, 3-methylenedioxyanilino) -7- [ 2- (4-methylpiperazin-1-yl) ethoxy ] -5-tetrahydropyran-4-yloxyquinazoline, intermediates and crystalline salts thereof | ASTRAZENECA AB (SE) | 2008-01-30 | — | — | CN | disclosed |
| CN-101072758-A | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-11-14 | — | — | CN | disclosed |
| CN-100347169-C | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-11-07 | — | — | CN | disclosed |
| US-7291641-B2 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2007-11-06 | — | — | US | disclosed |
| CN-101061121-A | Method for producing benzo [ c ] phenanthridine derivative | NIPPON KAYAKU KK (JP) | 2007-10-24 | — | — | CN | disclosed |
| CN-101056639-A | Thiazolopyridine kinase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2007-10-17 | — | — | CN | disclosed |
| CN-101035766-A | 3-(2-hydroxyphenyl) pyrazoles and their use as HSP90 modulators | MERCK PATENT GMBH (DE) | 2007-09-12 | — | — | CN | disclosed |
| US-20070179153-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S) | 2007-08-02 | — | — | US | disclosed |
| CN-101006061-A | 1,5-diphenylpyrazoles | MERCK PATENT GMBH (DE) | 2007-07-25 | — | — | CN | disclosed |
| EP-1802602-A1 | SUBSTITUTED DIPIPERDINE CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-04 | — | — | EP | disclosed |
| CN-1956964-A | Tetrahydro-indazole cannabinoid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2007-05-02 | — | — | CN | disclosed |
| CN-1950375-A | Glucocorticoid receptor modulator compounds and methods- utility | LIGAND PHARM INC (US) | 2007-04-18 | — | — | CN | disclosed |
| CN-1938282-A | Imidazole derivatives as tyrosine kinase inhibitors | MERCK PATENT GMBH (DE) | 2007-03-28 | — | — | CN | disclosed |
| US-20070054900-A1 | 4-Phenlthiazole and 4-phenylimidizole derivatives and their use as medicaments for the treatment of neurodegenerative diseases, pain and epilepsy | SOCIETE DE CONSEILS DE RECHERCHES ET (FR) | 2007-03-08 | — | — | US | disclosed |
| US-20070021390-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | SCRAS | 2007-01-25 | — | — | US | disclosed |
| CN-1894210-A | Prolinylarylacetamides | MERCK PATENT GMBH (DE) | 2007-01-10 | — | — | CN | disclosed |
| WO-2006135629-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING ALKYLQUINOLINES AND ALKYLQUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |
| CN-1878777-A | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2006-12-13 | — | — | CN | disclosed |
| EP-1682516-A2 | IMMOBILIZED N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES FOR THE IDENTIFICATION OF BIOMOLECULAR TARGETS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-26 | — | — | EP | disclosed |
| CN-1250624-C | Stabilising composition I | BASF AG (DE) | 2006-04-12 | — | — | CN | disclosed |
| WO-2006036527-A1 | SUBSTITUTED DIPIPERDINE CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-04-06 | — | — | WO | disclosed |
| CN-1747730-A | Pyrazole derivatives modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP (US) | 2006-03-15 | — | — | CN | disclosed |
| CN-1708303-A | pyridylalkyl-aminoalkyl-1H-indole derivatives as antidepressants and anxiolytics having 5-HT and serotonin reuptake inhibition | MERCK PATENT GMBH (DE) | 2005-12-14 | — | — | CN | disclosed |
| CN-1705670-A | 2, 3-dihydro-6-nitroimidazo [2, 1-b ] oxazole compounds | OTSUKA PHARMA CO LTD (JP) | 2005-12-07 | — | — | CN | disclosed |
| CN-1227248-C | Imidazolidine derivatives, their preparation, and their use as antinflamatory agent | AVENTIS PHARMA GMBH (DE) | 2005-11-16 | — | — | CN | disclosed |
| CN-1678562-A | Method for the enantioselective hydrogenation of amino alcohols | MERCK PATENT GMBH (DE) | 2005-10-05 | — | — | CN | disclosed |
| CN-1221535-C | Spiroimidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them | AVENTIS PHARMA GMBH (DE) | 2005-10-05 | — | — | CN | disclosed |
| CN-1674893-A | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2005-09-28 | — | — | CN | disclosed |
| CN-1668601-A | N-substituted tricyclic 3-aminopyrazoles as PDFG receptor inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-14 | — | — | CN | disclosed |
| CN-1662529-A | Thiazole derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2005-08-31 | — | — | CN | disclosed |
| CN-1216884-C | Dibenzo [ a, g ] quinolizinium derivatives and salts thereof | HANWHA PETRO CHEMICALS CO LTD (KR) | 2005-08-31 | — | — | CN | disclosed |
| CN-1659148-A | Aryloximes | MERCK PATENT GMBH (DE) | 2005-08-24 | — | — | CN | disclosed |
| CN-1639115-A | Semicarbazide derivatives and their use as antithrombotics | MERCK PATENT GMBH (DE) | 2005-07-13 | — | — | CN | disclosed |
| WO-2005049579-A2 | IMMOBILIZED N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES FOR THE IDENTIFICATION OF BIOMOLECULAR TARGETS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-06-02 | — | — | WO | disclosed |
| CN-1604933-A | Stabilising composition I | BASF AG (DE) | 2005-04-06 | — | — | CN | disclosed |
| CN-1604934-A | Stable compositions II | BASF AG (DE) | 2005-04-06 | — | — | CN | disclosed |
| US-20050038087-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | IPSEN PHARMA S.A.S. (FR) | 2005-02-17 | — | — | US | disclosed |
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| CN-1582148-A | Derivatives of phenoxy-n-'4-(isothiazolidin-1,1-dioxid-2yl)pheny!-valerian- acid amide and other compounds as inhibitors of the coagulation factor Xa in the treatment of thromboembolic diseases and tu | MERCK PATENT GMBH (DE) | 2005-02-16 | — | — | CN | disclosed |
| CN-1537000-A | Novel imidazolidine derivatives, their preparation and their use as VLA-4 antagonists | ������ҽҩ�¹�����˾ | 2004-10-13 | — | — | CN | disclosed |
| CN-1524072-A | Prenyl-containing derivatives and their use in the treatment of thromboembolic disorders or tumours | Ĭ��ר���ɷ�����˾ | 2004-08-25 | — | — | CN | disclosed |
| CN-1162427-C | Amine derivatives compounds | ������������ʽ���� | 2004-08-18 | — | — | CN | disclosed |
| CN-1520314-A | Medicine containing chymase inhibitor and ACE inhibitor as effective components | 帝人株式会社 | 2004-08-11 | — | — | CN | disclosed |
| CN-1518541-A | Phenyl derivatives | Ĭ��ר���ɷ�����˾ | 2004-08-04 | — | — | CN | disclosed |
| CN-1158256-C | Pyrrolidine derivatives-CCR-3 receptor antagonists | - | 2004-07-21 | — | — | CN | disclosed |
| US-20040132788-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2004-07-08 | — | — | US | disclosed |
| CN-1498206-A | Biurethane derivatives | Ĭ��ר���ɷ�����˾ | 2004-05-19 | — | — | CN | disclosed |
| CN-1496360-A | Imidazolidine derivatives, their preparation, and their use as antinflamatory agent | ������ҽҩ�¹�����˾ | 2004-05-12 | — | — | CN | disclosed |
| CN-1496361-A | Phenyl derivatives 3 | Ĭ��ר���ɷ�����˾ | 2004-05-12 | — | — | CN | disclosed |
| CN-1471527-A | Quinazoline derivatives | — | 2004-01-28 | — | — | CN | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |
| CN-1444571-A | Urethane derivatives | MERCK PATENT GMBH (DE) | 2003-09-24 | — | — | CN | disclosed |
| CN-1444561-A | Acetamide derivatives and their use as coagulation factor XA and VIIA inhibitors | MERCK PATENT GMBH (DE) | 2003-09-24 | — | — | CN | disclosed |
| CN-1443160-A | N-substituted-1-amino-1,1-dialkyl carboxylic acid derivatives | MERCK PATENT GMBH (DE) | 2003-09-17 | — | — | CN | disclosed |
| CN-1117055-C | Pesticide compounds, compositions and process for preparation thereof | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 2003-08-06 | — | — | CN | disclosed |
| CN-1356986-A | Spiroimidazolidine derivatives, their prepn. their use and pharmaceutical prepns. comprising them | AVENTIS PHARMA GMBH (DE) | 2002-07-03 | — | — | CN | disclosed |
| CN-1355448-A | Photosensitive lithographic printing plate | FUJI PHOTO FILM CO LTD (JP) | 2002-06-26 | — | — | CN | disclosed |
| CN-1354750-A | Amine derivatives compounds | SANKYO CO (JP) | 2002-06-19 | — | — | CN | disclosed |
| EP-0777680-B1 | UROKINASE RECEPTOR LIGANDS | CHIRON CORP (US) | 2002-03-20 | — | — | EP | disclosed |
| CN-1331677-A | Pyrrolidine derivatives-CCR-3 receptor antagonists | HOFFMANN LA ROCHE (CH) | 2002-01-16 | — | — | CN | disclosed |
| CN-1330650-A | Dibenzo [ a, g ] quinolizinium derivatives and salts thereof | HANWHA PETRO CHEMICALS CO LTD (KR) | 2002-01-09 | — | — | CN | disclosed |
| CN-1072660-C | 2,1,3-benzothia (oxa) diazole derivatives having an endothelin receptor antagonistic effect | MERCK PATENT GMBH (DE) | 2001-10-10 | — | — | CN | disclosed |
| EP-1113800-A1 | COMBINATIONS OF TETRACYCLIC CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS WITH FURTHER THERAPEUTIC AGENTS | ICOS CORPORATION (US) | 2001-07-11 | — | — | EP | disclosed |
| CN-1067992-C | Substituted thiazolidine derivatives and pharmaceutical compositions containing them and use thereof | OTSUKA PHARMA CO LTD (JP) | 2001-07-04 | — | — | CN | disclosed |
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| CN-1281451-A | Benzamidine derivatives | MERCK PATENT GMBH (DE) | 2001-01-24 | — | — | CN | disclosed |
| CN-1252070-A | 5,7-disubstituted 4-aminopyrido [2,3,-d] pyrimidine compounds and their use as adenosine kinase inhibitors | ABBOTT LAB (US) | 2000-05-03 | — | — | CN | disclosed |
| CN-1252069-A | 5,6, 7-trisubstituted-4-aminopyrido [2, 3-d ] pyrimidine compounds | ABBOTT LAB (US) | 2000-05-03 | — | — | CN | disclosed |
| WO-2000015228-A1 | COMBINATIONS OF TETRACYCLIC CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS WITH FURTHER THERAPEUTIC AGENTS | ICOS CORPORATION (US) | 2000-03-23 | — | — | WO | disclosed |
| WO-2000012495-A1 | USE OF DIHYDROPYRAN CARBOXYLIC ACID AMIDES AS HERBICIDES AND NEW DIHYDROPYRAN CARBOXYLIC ACID AMIDES | BASF AKTIENGESELLSCHAFT (DE) | 2000-03-09 | — | — | WO | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |
| EP-0946587-A2 | NEW AMIDE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-06 | — | — | EP | disclosed |
| CN-1216540-A | 2,1,3-benzothia (oxa) diazole derivatives having an endothelin receptor antagonistic effect | MERCK PATENT GES MIT BESCHRIKT (DE) | 1999-05-12 | — | — | CN | disclosed |
| CN-1206395-A | Pesticide compounds, compositions and process for preparation thereof | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1999-01-27 | — | — | CN | disclosed |
| WO-1998043649-A2 | AGE PRODUCTION INHIBITORY COMPOSITION COMPRISING A MAILLARD REACTION INHIBITOR AND VITAMIN B¿6? | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-10-08 | — | — | WO | disclosed |
| WO-1998027108-A2 | NEW AMIDE COMPOUNDS AND THEIR USE AS NITRIC OXIDE SYNTHASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-25 | — | — | WO | disclosed |
| CN-1184105-A | Substituted thiazolidine derivatives and pharmaceutical compositions containing them and use thereof | OTSUKA PHARMA CO LTD (JP) | 1998-06-10 | — | — | CN | disclosed |
| CN-1037842-C | Substituted thiazolidine derivatives, pharmaceutical compositions and uses thereof | OTSUKA PHARMA CO LTD (JP) | 1998-03-25 | — | — | CN | disclosed |
| CN-1171394-A | New urea derivatives, their preparation and their therapeutic and prophylactic use | SANKYO CO (JP) | 1998-01-28 | — | — | CN | disclosed |
| CN-1155539-A | Endothelin receptor antagonists | MERCK PATENT GMBH (DE) | 1997-07-30 | — | — | CN | disclosed |
| CN-1149583-A | Enderma agent receptor antagonist | MERCK PATENT GMBH (DE) | 1997-05-14 | — | — | CN | disclosed |
| EP-0667858-A1 | 4-CARBOXOAMIDO PIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS NEUROKININ ANTAGONISTS | ZENECA LIMITED (GB) | 1995-08-23 | — | — | EP | disclosed |
| CN-1106982-A | Maillard reaction inhibitor | OTSUKA PHARMA CO LTD (JP) | 1995-08-16 | — | — | CN | disclosed |
| CN-1100262-A | New herbicides | RHONE POULENC AGRICULTURE (GB) | 1995-03-22 | — | — | CN | disclosed |
| CN-1093360-A | The lithium salts of 2-O-alkyl ascorbic acid | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-10-12 | — | — | CN | disclosed |
| CN-1026111-C | Quinuclidine therapeutic agents | PFIZER (US) | 1994-10-05 | — | — | CN | disclosed |
| CN-1043130-A | QUINUCLIDINE THERAPEUTIC AGENTS | PFIZER (US) | 1990-06-20 | — | — | CN | disclosed |
| CN-1043130-A | QUINUCLIDINE THERAPEUTIC AGENTS | PFIZER (US) | 1990-06-20 | — | — | CN | disclosed |