Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 11/20 | 0.78 |
| ▸ | WEE1 | P30291 | 1/20 | 0.59 |
| ▸ | CDK4 | P11802 | 8/20 | 0.58 |
| ▸ | CCND1 | P24385 | 7/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.58 |
| ▸ | CDK2 | P24941 | 5/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.58 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.58 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.58 |
| ▸ | CCND2 | P30279 | 4/20 | 0.57 |
| ▸ | CCND3 | P30281 | 4/20 | 0.57 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.57 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.57 |
| ▸ | MARK3 | P27448 | 1/20 | 0.57 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.57 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.57 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.57 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3530132 | 0.99 | CSF1R (0.79) | CSF1RWEE1CDK4CCND1CCNA2 | |
| SCHEMBL3527206 | 0.90 | CSF1R (0.65) | CSF1RWEE1CDK4CCND1CCNA2 | |
| SCHEMBL4791572 | 0.89 | CSF1R (0.86) | CSF1RWEE1CDK4CCND1CCNA2 | |
| SCHEMBL4572719 | 0.88 | CSF1R (0.77) | CSF1RWEE1CDK4CCND1CCNA2 | |
| SCHEMBL4892216 | 0.88 | CSF1R (0.72) | CSF1RCDK4CCND1CCNA2CDK2 | |
| SCHEMBL3527526 | 0.88 | CSF1R (1.00) | CSF1RWEE1CDK4CCND1CCNA2 | |
| SCHEMBL4767401 | 0.88 | CSF1R (0.86) | CSF1RWEE1CDK4CCND1CCNA2 | |
| SCHEMBL3530652 | 0.88 | CSF1R (0.80) | CSF1RWEE1CDK4CCND1CCNA2 | |
| SCHEMBL3530467 | 0.87 | CSF1R (1.00) | CSF1RWEE1CDK4CCND1CCNA2 | |
| SCHEMBL3525991 | 0.87 | CSF1R (0.80) | CSF1RWEE1CDK4CCND1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642270-B2 | 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-01-05 | — | — | US | disclosed |
| US-20070060577-A1 | 5-Oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060577-A1 | 5-Oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase | FLT3, FES, FGR | CSF1R 427/4885WEE1 154/4885CDK4 212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.