Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 4/20 | 0.47 |
| ▸ | HTR6 | P50406 | 8/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3536099 | 0.91 | HTR1B (0.54) | HTR1BHTR6BCHEHTR1DKDM4E | |
| SCHEMBL3529159 | 0.83 | HTR1B (0.48) | HTR1BHTR6HTR1DHTR1ADRD2 | |
| SCHEMBL3535014 | 0.83 | HTR6 (0.45) | HTR1BHTR6KMT2AHTR1DHTR1A | |
| SCHEMBL3538879 | 0.82 | HTR1B (0.47) | HTR1BHTR6HTR1DKDM4EHTR1A | |
| SCHEMBL3529169 | 0.81 | HTR6 (0.43) | HTR1BHTR6BCHEKMT2AHTR1A | |
| SCHEMBL3532652 | 0.81 | HTR1B (0.52) | HTR1BHTR6HTR1DHTR1ADRD2 | |
| SCHEMBL3534202 | 0.80 | TDP1 (0.48) | HTR1BHTR6BCHETDP1KMT2A | |
| SCHEMBL3538306 | 0.79 | HTR6 (0.48) | HTR1BHTR6BCHETDP1KMT2A | |
| SCHEMBL3531498 | 0.78 | HTR1B (0.48) | HTR1BHTR6BCHE | |
| SCHEMBL3529592 | 0.74 | HTR1B (0.44) | HTR1BHTR6BCHEHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723329-B2 | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2010-05-25 | — | — | US | claimed |