2-Pyrrolidone

2-Pyrrolidone

SCHEMBL4655461

O=C1CCCN1.O=C1CCCN1.OO

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
OR51E2 Q9H255 1/20 0.88
CRBN Q96SW2 5/20 0.74
FKBP5 Q13451 1/20 0.74
KDM4E B2RXH2 3/20 0.48
GAA P10253 2/20 0.48
POLB P06746 1/20 0.48
KMT2A Q03164 2/20 0.35
MAPT P10636 2/20 0.35
LMNA P02545 1/20 0.33
HSD17B10 Q99714 1/20 0.33
MEN1 O00255 1/20 0.32
TSHR P16473 1/20 0.32
MAPK1 P28482 1/20 0.32
HSP90AA1 P07900 1/20 0.31
GRIA1 P42261 1/20 0.31
GRIA2 P42262 1/20 0.31
GRIA3 P42263 1/20 0.31
GRIA4 P48058 1/20 0.31
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Pyrrolidone SCHEMBL3356160 1.00
2-Pyrrolidone SCHEMBL28107340 0.95 OR51E2 (0.79) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL14977810 0.95 OR51E2 (0.79) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL14977562 0.95 OR51E2 (0.79) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL6929736 0.95 OR51E2 (0.79) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL353224 0.95 OR51E2 (0.79) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL27827832 0.94
2-Pyrrolidone SCHEMBL4299593 0.94
2-Pyrrolidone SCHEMBL9304498 0.94 OR51E2 (1.00) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL2389 0.94

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4294357-A1 ORAL CARE COMPOSITIONS COMPRISING PEROXIDE AND ALUMINA The Procter & Gamble Company (US) 2023-12-27 EP claimed
EP-4294354-A1 HYDRATING ORAL CARE COMPOSITIONS COMPRISING PEROXIDE The Procter & Gamble Company (US) 2023-12-27 EP claimed
EP-4294355-A1 ORAL CARE COMPOSITIONS COMPRISING PEROXIDE AND COMPATIBLE ABRASIVE The Procter & Gamble Company (US) 2023-12-27 EP claimed
EP-4294356-A1 ORAL CARE COMPOSITION COMPRISING PEROXIDE The Procter & Gamble Company (US) 2023-12-27 EP claimed
US-20220265531-A1 ORAL CARE COMPOSITIONS COMPRISING PEROXIDE AND COMPATIBLE ABRASIVE THE PROCTER & GAMBLE COMPANY 2022-08-25 US claimed
WO-2022178531-A1 ORAL CARE COMPOSITIONS COMPRISING PEROXIDE AND ALUMINA THE PROCTER & GAMBLE COMPANY (US) 2022-08-25 WO claimed
US-20220265532-A1 ORAL CARE COMPOSITIONS COMPRISING PEROXIDE AND ALUMINA THE PROCTER & GAMBLE COMPANY 2022-08-25 US claimed
CN-107252398-A Oral care Lightening compositions 高露洁-棕榄公司 2017-10-17 CN claimed
CN-1089251-C Steam sterilization using anhydrous hydrogen peroxide source JOHNSON & JOHNSON MEDICAL (US) 2002-08-21 CN claimed
CN-1112446-A Steam sterilization using anhydrous hydrogen peroxide source JOHNSON & JOHNSON MEDICAL (US) 1995-11-29 CN claimed
EP-3894388-A1 (METH)ACRYLATE-FUNCTIONALIZED WAXES AND CURABLE COMPOSITIONS MADE THEREWITH Henkel IP & Holding GmbH (DE) 2021-10-20 EP disclosed
EP-3119698-B1 HYDROGEN PEROXIDE VAPOUR GENERATING PRODUCT AND METHOD COOLSAN HYGIENE SOLUTIONS PTY LTD (AU) 2020-09-09 EP disclosed
WO-2020119908-A1 (METH)ACRYLATE-FUNCTIONALIZED WAXES AND CURABLE COMPOSITIONS MADE THEREWITH Henkel IP & Holding GmbH (DE) 2020-06-18 WO disclosed
WO-2018215789-A1 ORAL CARE COMPOSITION, PROCESS FOR PREPARATION AND METHOD OF USE THEREOF BIOFILM LIMITED (GB) 2018-11-29 WO disclosed
US-9770402-B2 Oral care compositions COLGATE-PALMOLIVE COMPANY (US) 2017-09-26 US disclosed
US-20060171905-A1 Dental bleaching compositions having a protective coating applied thereto ULTRADENT PRODUCTS, INC. 2006-08-03 US disclosed
WO-2006034249-A2 ANTIMICROBIAL AMORPHOUS COMPOSITIONS ACRYMED, INC. (US) 2006-03-30 WO disclosed
CN-1089251-C Steam sterilization using anhydrous hydrogen peroxide source JOHNSON & JOHNSON MEDICAL (US) 2002-08-21 CN disclosed
CN-1121314-A Improvements in or relating to contrast agents NYCOMED IMAGING AS (NO) 1996-04-24 CN disclosed
CN-1112446-A Steam sterilization using anhydrous hydrogen peroxide source JOHNSON & JOHNSON MEDICAL (US) 1995-11-29 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220265532-A1 ORAL CARE COMPOSITIONS COMPRISING PEROXIDE AND ALUMINA CAT, POLN, SOD3 OR51E2 1684/4885CRBN 1022/4885FKBP5 4770/4885
US-20220265531-A1 ORAL CARE COMPOSITIONS COMPRISING PEROXIDE AND COMPATIBLE ABRASIVE LBR, AP3S1, PHOSPHO1 OR51E2 3551/4885CRBN 1341/4885FKBP5 4157/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.