Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.53 |
| ▸ | HTR2B | P41595 | 5/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3532495 | 0.97 | HTR6 (0.52) | HTR6HTR2BDRD2HTR2CTP53 | |
| SCHEMBL3538468 | 0.94 | HTR6 (0.59) | HTR6HTR2BDRD2HTR2CNR1I2 | |
| SCHEMBL3530834 | 0.91 | HTR6 (0.58) | HTR6HTR2BDRD2HTR2CNR1I2 | |
| SCHEMBL3534496 | 0.89 | HTR6 (0.52) | HTR6HTR2BDRD2HTR2CTP53 | |
| SCHEMBL3531338 | 0.88 | HTR6 (0.53) | HTR6HTR2BDRD2HTR2CTP53 | |
| SCHEMBL3532651 | 0.88 | HTR6 (0.53) | HTR6HTR2BDRD2HTR2CTP53 | |
| SCHEMBL3534239 | 0.87 | HTR6 (0.52) | HTR6HTR2BDRD2HTR2CTP53 | |
| SCHEMBL3531961 | 0.87 | HTR6 (0.56) | HTR6HTR2BDRD2HTR2CHTR1A | |
| SCHEMBL3532494 | 0.87 | HTR6 (0.52) | HTR6HTR2BDRD2HTR2CTP53 | |
| SCHEMBL3527946 | 0.86 | HTR6 (0.53) | HTR6HTR2BDRD2HTR2CTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723329-B2 | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2010-05-25 | — | — | US | claimed |