⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21692802 | 0.71 | CA1 (0.34) | — | |
| SCHEMBL28939794 | 0.69 | — | — | |
| SCHEMBL329182 | 0.67 | — | — | |
| SCHEMBL22494211 | 0.67 | — | — | |
| SCHEMBL3585438 | 0.67 | — | — | |
| SCHEMBL6347129 | 0.67 | — | — | |
| SCHEMBL24393378 | 0.66 | CA12 (0.31) | — | |
| SCHEMBL27692929 | 0.65 | — | — | |
| SCHEMBL27534262 | 0.65 | TP53 (0.36) | — | |
| SCHEMBL6826771 | 0.64 | CA2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 301 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110372563-A | A kind of mild substituted azole sulfonamide deprotection method | 大连理工大学 | 2019-10-25 | — | — | CN | claimed |
| EP-1174151-B1 | THERAPEUTIC TREATMENT OF EOSINOPHILIA USING CHYMASE INHIBITORS AS THE ACTIVE INGREDIENT | DAIICHI ASUBIO PHARMA CO LTD (JP) | 2007-01-24 | — | — | EP | claimed |
| US-7057036-B2 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2006-06-06 | — | — | US | claimed |
| US-20050038242-A2 | PYRROLOTHIAZINE AND PYRROLOTHIAZEPHINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA-1-BLOCKING ACTION | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2005-02-17 | — | — | US | claimed |
| US-20040127705-A1 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-07-01 | — | — | US | claimed |
| US-6743913-B2 | POTENCY, SELECTIVITY; REDUCED SIDE EFFECTS; CONVERTING PYRROLE-3-SULFONIC ACID TO SULFONYL CHLORIDE FORM; REACTING WITH AMINOACETIC ACID, AMINOPROPIONIC ACID OR DERIVATIVE; RING CLOSURE | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2004-06-01 | — | — | US | claimed |
| US-6677344-B2 | Chymase inhibitor for the treatment of eosinophilia | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2004-01-13 | — | — | US | claimed |
| US-20030229070-A1 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonist and alpha-1-blocking action | DAIICHI SUNTORY PHARMA CO., LTD (JP) | 2003-12-11 | — | — | US | claimed |
| US-6500835-B2 | FOR PROPHYLAXIS AND THERAPY OF FIBROSIS INVOLVING EXTRACELLULAR MATRIX DYSBOLISM HAVING A CHYMASE INHIBITOR AS AN EFFECTIVE INGREDIENT; SIDE EFFECT REDUCTION | SUNTORY LIMITED (JP) | 2002-12-31 | — | — | US | claimed |
| US-20020137928-A1 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action | SUNTORY LIMITED (JP) | 2002-09-26 | — | — | US | claimed |
| WO-2002036113-A1 | COMPOSITION COMPRISING: SEROTONIN RECEPTOR ANTAGONISTS (5HT-2, 5HT-3) AND AGONIST (5HT-4) | RESPIRATORIUS AB (SE) | 2002-05-10 | — | — | WO | claimed |
| US-20020040017-A1 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action | SUNTORY LIMITED (JP) | 2002-04-04 | — | — | US | claimed |
| US-6331623-B1 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | claimed |
| US-6271223-B1 | CARDIOVASCULAR DISORDERS | SUNTORY LIMITED (JP) | 2001-08-07 | — | — | US | claimed |
| WO-1999033841-B1 | PYRROLOTHIAZINE AND PYRROLOTHIAZEPINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA-1-BLOCKING ACTION | SUNTORY LTD (JP) | 2001-05-25 | — | — | WO | claimed |
| EP-0970088-A2 | PYRROLOTHIAZINE AND PYRROLOTHIAZEPINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA1-BLOCKING ACTION | SUNTORY LIMITED (JP) | 2000-01-12 | — | — | EP | claimed |
| EP-0970089-A2 | PYRROLOTHIAZINE AND PYRROLOTHIAZEPINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA-1-BLOCKING ACTION | SUNTORY LIMITED (JP) | 2000-01-12 | — | — | EP | claimed |
| WO-1999033840-B1 | PYRROLOTHIAZINE AND PYRROLOTHIAZEPINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA1-BLOCKING ACTION | SUNTORY LTD (JP) | 1999-10-14 | — | — | WO | claimed |
| WO-1999033841-A2 | PYRROLOTHIAZINE AND PYRROLOTHIAZEPINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA-1-BLOCKING ACTION | SUNTORY LIMITED (JP) | 1999-07-08 | — | — | WO | claimed |
| WO-1999033840-A2 | PYRROLOTHIAZINE AND PYRROLOTHIAZEPINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA1-BLOCKING ACTION | SUNTORY LIMITED (JP) | 1999-07-08 | — | — | WO | claimed |