Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.71 |
| ▸ | BTK | Q06187 | 2/20 | 0.69 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.69 |
| ▸ | CSK | P41240 | 1/20 | 0.69 |
| ▸ | CAMK1G | Q96NX5 | 1/20 | 0.69 |
| ▸ | CCR4 | P51679 | 1/20 | 0.66 |
| ▸ | MELK | Q14680 | 4/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.60 |
| ▸ | FER | P16591 | 1/20 | 0.60 |
| ▸ | MATK | P42679 | 1/20 | 0.60 |
| ▸ | BLK | P51451 | 1/20 | 0.60 |
| ▸ | BMX | P51813 | 1/20 | 0.60 |
| ▸ | TEK | Q02763 | 1/20 | 0.60 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.60 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.60 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3536852 | 1.00 | FLT3 (0.71) | FLT3BTKERBB4CSKCAMK1G | |
| SCHEMBL7619472 | 0.90 | BTK (0.71) | FLT3BTKERBB4CSKCAMK1G | |
| SCHEMBL7619465 | 0.90 | BTK (0.71) | FLT3BTKERBB4CSKCAMK1G | |
| SCHEMBL3542142 | 0.89 | CCR4 (0.72) | FLT3BTKERBB4CSKCAMK1G | |
| SCHEMBL3542141 | 0.89 | CCR4 (0.72) | FLT3BTKERBB4CSKCAMK1G | |
| SCHEMBL13783483 | 0.86 | FLT3 (0.73) | FLT3BTKERBB4CSKCAMK1G | |
| SCHEMBL3541032 | 0.85 | CCR4 (0.71) | FLT3BTKERBB4CSKCAMK1G | |
| SCHEMBL3541029 | 0.85 | CCR4 (0.71) | FLT3BTKERBB4CSKCAMK1G | |
| SCHEMBL7828205 | 0.85 | CXCR4 (0.61) | FLT3BTKERBB4CSKCAMK1G | |
| SCHEMBL1612950 | 0.85 | BTK (0.76) | FLT3BTKERBB4CSKCAMK1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829566-B2 | Such as (7-chloro-2-styryl-quinazolin-4-yl)-(3-imidazol-1-yl-propyl)-amine; glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | MEDERSKI WERNER | 2010-11-09 | — | — | US | disclosed |
| US-20070293667-A1 | 4-Amino-quinazolines | MEDERSKI WERNER | 2007-12-20 | — | — | US | disclosed |
| US-20040044204-A1 | 4-amino-quinazolines | ORTHO-MCNEIL PHARMACEUTICALS, INC. | 2004-03-04 | — | — | US | disclosed |
| US-6444434-B1 | COMPOUNDS INHIBITING THE ACTIVATION OF FX TO FXA BY TF/FVIIA. THE COMPOUNDS ARE ANTICOAGULANTS. THE INVENTION ALSO RELATES TO A METHOD OF IDENTIFYING A DRUG CANDIDATE. | NOVO NORDISK A/S (DK) | 2002-09-03 | — | — | US | disclosed |
| US-6238878-B1 | DRUG SCREENING OF FACTOR VIII-TISSUE FACTOR INHIBITORS BY TESTING EFFECT ON FACTOR X ACTIVATION, FACTOR XA AMIDOLYTIC ASSAY, AND TISSUE FACTOR/FACTOR VIIA AMIDOLYTIC ASSAY; THEN SELECTING COMPOUND BASED ON RESULTS | NOVO NORKISK AIS (DK) | 2001-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044204-A1 | 4-amino-quinazolines | MRGPRX4, MRGPRX1, MRGPRX2 | FLT3 493/4885BTK 1084/4885ERBB4 487/4885 |
| US-20070293667-A1 | 4-Amino-quinazolines | MRGPRX4, MRGPRX1, MRGPRX2 | FLT3 224/4885BTK 766/4885ERBB4 601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.