Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 8/20 | 0.72 |
| ▸ | FLT1 | P17948 | 7/20 | 0.65 |
| ▸ | ITK | Q08881 | 3/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | CLK3 | P49761 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3533364 | 0.78 | FGFR1 (0.85) | FGFR1FLT1ITKLRRK2ABL1 | |
| SCHEMBL30222327 | 0.76 | FGFR1 (0.68) | FGFR1FLT1ITKKDM4EALDH1A1 | |
| SCHEMBL5952268 | 0.74 | FGFR1 (0.67) | FGFR1FLT1ITKKDM4EALDH1A1 | |
| SCHEMBL5866739 | 0.74 | FGFR1 (0.64) | FGFR1FLT1ITKLRRK2ABL1 | |
| SCHEMBL311148 | 0.72 | FGFR1 (1.00) | FGFR1FLT1ITKKDM4EALDH1A1 | |
| SCHEMBL29714859 | 0.72 | FGFR1 (1.00) | FGFR1FLT1ITKKDM4EALDH1A1 | |
| SCHEMBL29548155 | 0.72 | LRRK2 (0.72) | FGFR1FLT1ITKLRRK2KDM4E | |
| SCHEMBL26911852 | 0.72 | LRRK2 (0.72) | FGFR1FLT1ITKLRRK2KDM4E | |
| SCHEMBL146694 | 0.71 | KDM4E (0.53) | FGFR1KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL4920662 | 0.71 | FGFR1 (0.60) | FGFR1FLT1ITKKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642278-B2 | Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-7064215-B2 | Indazole benzimidazole compounds | CHIRON CORPORATION (US) | 2006-06-20 | — | — | US | disclosed |
| US-20060079564-A1 | Indazole benzimidazole compounds | CHIRON CORPORATION | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079564-A1 | Indazole benzimidazole compounds | ABL1, ABL2, ALK | FGFR1 886/4885FLT1 2793/4885ITK 1055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.