Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.58 |
| ▸ | CDK4 | P11802 | 5/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.58 |
| ▸ | IKBKB | O14920 | 1/20 | 0.56 |
| ▸ | CHUK | O15111 | 1/20 | 0.56 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 6/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3537197 | 1.00 | CDK2 (0.58) | CDK2CDK4CCNE1IKBKBCHUK | |
| SCHEMBL3541269 | 0.86 | CDK2 (0.60) | CDK2CDK4IKBKBCHUKIKBKG | |
| SCHEMBL3539937 | 0.86 | CDK2 (0.60) | CDK2CDK4IKBKBCHUKIKBKG | |
| SCHEMBL3539933 | 0.86 | CDK2 (0.60) | CDK2CDK4IKBKBCHUKIKBKG | |
| SCHEMBL3540121 | 0.84 | CDK2 (0.66) | CDK2CDK4CCNE1IKBKBCHUK | |
| SCHEMBL3611097 | 0.81 | CDK2 (0.61) | CDK2CDK4CCNE1IKBKBCHUK | |
| SCHEMBL1684693 | 0.80 | CDK2 (0.80) | CDK2CDK4CCNE1IKBKBCHUK | |
| SCHEMBL1684670 | 0.80 | CDK2 (0.76) | CDK2CDK4CCNE1IKBKBCDK1 | |
| SCHEMBL3542122 | 0.79 | CDK2 (0.58) | CDK2CDK4CCNE1IKBKBCHUK | |
| SCHEMBL2882904 | 0.79 | IKBKB (0.57) | CDK2IKBKBCHUKIKBKGCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745428-B2 | Imidazo[1,2-A]pyridine having anti-cell-proliferation activity | ASTRAZENECA AB (SE) | 2010-06-29 | — | — | US | claimed |
| EP-1934213-A1 | IMIDAZO [1,2-A] PYRIDINE HAVING ANTI-CELL-PROLIFERATION ACTIVITY | Astra Zeneca AB (SE) | 2008-06-25 | — | — | EP | claimed |
| WO-2007036732-A1 | IMIDAZO [1,2-A] PYRIDINE HAVING ANTI-CELL-PROLIFERATION ACTIVITY | ASTRAZENECA AB (SE) | 2007-04-05 | — | — | WO | claimed |