Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.61 |
| ▸ | CDK4 | P11802 | 5/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.61 |
| ▸ | CDK1 | P06493 | 3/20 | 0.54 |
| ▸ | SYK | P43405 | 3/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | ROS1 | P08922 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.52 |
| ▸ | MARK3 | P27448 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | CLK2 | P49760 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3540121 | 0.97 | CDK2 (0.66) | CDK2CDK4CCNE1CDK1SYK | |
| SCHEMBL3542122 | 0.90 | CDK2 (0.58) | CDK2CDK4CCNE1CDK1SYK | |
| SCHEMBL3542436 | 0.86 | CDK2 (0.65) | CDK2CDK4CDK1SYKIRAK4 | |
| SCHEMBL1684693 | 0.82 | CDK2 (0.80) | CDK2CDK4CCNE1CDK1GSK3B | |
| SCHEMBL1684670 | 0.82 | CDK2 (0.76) | CDK2CDK4CCNE1CDK1SYK | |
| SCHEMBL3534358 | 0.82 | CDK2 (0.69) | CDK2CDK4CDK1SYKIRAK4 | |
| SCHEMBL3537197 | 0.81 | CDK2 (0.58) | CDK2CDK4CCNE1CDK1SYK | |
| SCHEMBL3537192 | 0.81 | CDK2 (0.58) | CDK2CDK4CCNE1CDK1SYK | |
| SCHEMBL700913 | 0.81 | CDK2 (0.51) | CDK2CDK4CCNE1CDK1SYK | |
| SCHEMBL700985 | 0.81 | CDK2 (0.55) | CDK2CDK4CCNE1CDK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745428-B2 | Imidazo[1,2-A]pyridine having anti-cell-proliferation activity | ASTRAZENECA AB (SE) | 2010-06-29 | — | — | US | claimed |
| EP-1934213-A1 | IMIDAZO [1,2-A] PYRIDINE HAVING ANTI-CELL-PROLIFERATION ACTIVITY | Astra Zeneca AB (SE) | 2008-06-25 | — | — | EP | claimed |
| WO-2007036732-A1 | IMIDAZO [1,2-A] PYRIDINE HAVING ANTI-CELL-PROLIFERATION ACTIVITY | ASTRAZENECA AB (SE) | 2007-04-05 | — | — | WO | claimed |