Sugi Predict

Sugi Predict / Compounds / SCHEMBL3538583

SCHEMBL3538583

SCHEMBL3538583

COc1ccccc1Oc1ccc2[nH]nc(-c3nc4ccccc4n3C)c2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 1/20 0.47
▸ LRRK2 Q5S007 2/20 0.43
▸ RAB9A P51151 4/20 0.41
▸ NPC1 O15118 3/20 0.40
▸ SMN1; SMN2 Q16637 3/20 0.40
▸ TP53 P04637 2/20 0.40
▸ LMNA P02545 2/20 0.40
▸ GAA P10253 2/20 0.39
▸ KDR P35968 2/20 0.39
▸ PLK1 P53350 2/20 0.39
▸ PTK2 Q05397 2/20 0.39
▸ AURKB Q96GD4 2/20 0.39
▸ ADORA1 P30542 1/20 0.39
▸ AKT1 P31749 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ PKM P14618 1/20 0.39
▸ TTK P33981 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3532370 0.89 HTT (0.47) ABL1RAB9ANPC1SMN1; SMN2TP53
SCHEMBL3534827 0.89 LRRK2 (0.42) ABL1LRRK2RAB9ANPC1SMN1; SMN2
SCHEMBL3535791 0.88 TP53 (0.47) ABL1LRRK2RAB9ANPC1SMN1; SMN2
SCHEMBL3538710 0.87 CHEK2 (0.45) ABL1LRRK2RAB9ANPC1SMN1; SMN2
SCHEMBL3541984 0.87 ABL1 (0.42) ABL1LRRK2KDRKDM4E
SCHEMBL3538380 0.86 SCN9A (0.45) ABL1LRRK2RAB9ANPC1SMN1; SMN2
SCHEMBL3541863 0.86 TTK (0.40) ABL1LRRK2RAB9ANPC1LMNA
SCHEMBL3533928 0.83 ADORA1 (0.44) RAB9ANPC1SMN1; SMN2TP53LMNA
SCHEMBL3536646 0.83 DRD1 (0.42) LRRK2RAB9ANPC1LMNAGAA
SCHEMBL3544838 0.82 ABL1 (0.53) ABL1LRRK2LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-20060079564-A1 Indazole benzimidazole compounds CHIRON CORPORATION 2006-04-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060079564-A1 Indazole benzimidazole compounds ABL1, ABL2, ALK ABL1 1/4885LRRK2 672/4885RAB9A 2461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.