Sugi Predict

Sugi Predict / Compounds / SCHEMBL3534827

SCHEMBL3534827

SCHEMBL3534827

Cn1c(-c2n[nH]c3ccc(Oc4ccccc4F)cc23)nc2ccccc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LRRK2 Q5S007 3/20 0.42
▸ PPARG P37231 2/20 0.39
▸ LMNA P02545 2/20 0.39
▸ GAA P10253 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ PAX8 Q06710 1/20 0.39
▸ TTK P33981 1/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ RAB9A P51151 1/20 0.38
▸ GCK P35557 1/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ ABL1 P00519 1/20 0.37
▸ RPS6KB1 P23443 1/20 0.37
▸ GSK3B P49841 1/20 0.37
▸ RHEB Q15382 1/20 0.36
▸ SCN9A Q15858 1/20 0.36
▸ ITK Q08881 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3538380 0.90 SCN9A (0.45) LRRK2LMNAGAAKDM4EPAX8
SCHEMBL3538583 0.89 ABL1 (0.47) LRRK2LMNAGAAKDM4ETTK
SCHEMBL3542562 0.88 BRAF (0.39) LRRK2TTKGCKABL1MAPK1
SCHEMBL3538710 0.86 CHEK2 (0.45) LRRK2LMNAGAAKDM4EPAX8
SCHEMBL3536897 0.86 KDM4E (0.43) LRRK2PPARGLMNAGAAKDM4E
SCHEMBL3541863 0.85 TTK (0.40) LRRK2LMNAGAAKDM4EPAX8
SCHEMBL3532370 0.84 HTT (0.47) LMNAGAAKDM4EPAX8TTK
SCHEMBL3544861 0.83 FGFR1 (0.44) LRRK2PPARGABL1SCN9AFGFR1
SCHEMBL3536646 0.82 DRD1 (0.42) LRRK2PPARGLMNAGAAKDM4E
SCHEMBL3535791 0.82 TP53 (0.47) LRRK2GAAKDM4ETTKNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-20060079564-A1 Indazole benzimidazole compounds CHIRON CORPORATION 2006-04-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060079564-A1 Indazole benzimidazole compounds ABL1, ABL2, ALK LRRK2 672/4885PPARG 3905/4885LMNA 2670/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.