Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCND1 | P24385 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3540885 | 0.80 | HTR2C (0.47) | LIPGHPGDALDH1A1HSD17B10USP2 | |
| SCHEMBL3547592 | 0.79 | KMT2A (0.39) | HPGDALDH1A1HSD17B10USP2HTR2C | |
| SCHEMBL3539298 | 0.78 | HTR2C (0.46) | LIPGHPGDALDH1A1HSD17B10USP2 | |
| SCHEMBL3547101 | 0.71 | KCNQ2 (0.39) | — | |
| SCHEMBL13501879 | 0.71 | KCNQ2 (0.39) | LMNAGAA | |
| SCHEMBL3542971 | 0.71 | HTR2C (0.47) | LIPGHSD17B10KDM4EHTR2CMAPK1 | |
| SCHEMBL3544773 | 0.71 | HTR2C (0.47) | LIPGHSD17B10KDM4EHTR2CMAPK1 | |
| SCHEMBL3546198 | 0.60 | HTR2C (0.42) | HPGDALDH1A1HSD17B10USP2KDM4E | |
| SCHEMBL12179558 | 0.58 | MEN1 (0.41) | ALDH1A1KDM4EMEN1KMT2ATSHR | |
| SCHEMBL13501876 | 0.58 | HTR1A (0.35) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662831-B2 | Tetracyclic indoles as potassium channel modulators | WYETH LLC (US) | 2010-02-16 | — | — | US | disclosed |
| US-7662831-B2 | Tetracyclic indoles as potassium channel modulators | WYETH LLC (US) | 2010-02-16 | — | — | US | disclosed |
| US-7662831-B2 | Tetracyclic indoles as potassium channel modulators | WYETH LLC (US) | 2010-02-16 | — | — | US | disclosed |
| US-20080027090-A1 | TETRACYCLIC INDOLES AS POTASSIUM CHANNEL MODULATORS | WYETH (US) | 2008-01-31 | — | — | US | disclosed |
| US-20080027090-A1 | TETRACYCLIC INDOLES AS POTASSIUM CHANNEL MODULATORS | WYETH (US) | 2008-01-31 | — | — | US | disclosed |
| US-20080027090-A1 | TETRACYCLIC INDOLES AS POTASSIUM CHANNEL MODULATORS | WYETH (US) | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027090-A1 | TETRACYCLIC INDOLES AS POTASSIUM CHANNEL MODULATORS | KCNJ2, KCNA5, KCNK5 | LIPG 4649/4885HPGD 1689/4885ALDH1A1 1546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.