Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 20/20 | 0.89 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL353901 | 1.00 | MCHR1 (0.89) | MCHR1KCNH2HTR2C | |
| SCHEMBL10082855 | 0.95 | MCHR1 (0.80) | MCHR1KCNH2HTR2C | |
| SCHEMBL10082922 | 0.95 | MCHR1 (0.79) | MCHR1KCNH2HTR2C | |
| SCHEMBL10083245 | 0.94 | MCHR1 (1.00) | MCHR1 | |
| SCHEMBL10082878 | 0.91 | MCHR1 (0.73) | MCHR1KCNH2HTR2C | |
| SCHEMBL10082866 | 0.90 | MCHR1 (0.73) | MCHR1KCNH2HTR2C | |
| SCHEMBL10083250 | 0.89 | MCHR1 (0.90) | MCHR1 | |
| SCHEMBL10083246 | 0.89 | MCHR1 (0.90) | MCHR1 | |
| SCHEMBL10082867 | 0.89 | MCHR1 (0.71) | MCHR1KCNH2HTR2C | |
| SCHEMBL10082854 | 0.89 | MCHR1 (0.70) | MCHR1KCNH2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841290-B2 | Substituted tetrahydronaphthalenes, method for the production thereof, and use thereof as drugs | SANOFI (FR) | 2014-09-23 | — | — | US | disclosed |
| US-20120015936-A1 | SUBSTITUTED TETRAHYDRONAPHTHALENES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS DRUGS | SANOFI (FR) | 2012-01-19 | — | — | US | disclosed |
| EP-2396300-A1 | NEW SUBSTITUTED TETRAHYDRONAPTHALENES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS DRUGS | SANOFI (FR) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092153-A1 | NEW SUBSTITUTED TETRAHYDRONAPTHALENES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS DRUGS | SANOFI-AVENTIS (FR) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015936-A1 | SUBSTITUTED TETRAHYDRONAPHTHALENES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS DRUGS | PAH, MCHR1, DHPS | MCHR1 2/4885KCNH2 1429/4885HTR2C 447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.