Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3173622 | 0.80 | AKR1C3 (0.70) | MAPTPOLBGAAALDH1A1AKR1C3 | |
| SCHEMBL6867319 | 0.80 | MAPT (0.56) | MAPTPOLBGAAALDH1A1AKR1C3 | |
| SCHEMBL12527300 | 0.79 | AKR1C3 (0.68) | MAPTPOLBGAAALDH1A1AKR1C3 | |
| SCHEMBL9424119 | 0.78 | LMNA (0.62) | MAPTPOLBGAAALDH1A1AKR1C3 | |
| Nitrogen SCHEMBL9845855 | 0.77 | AKR1C3 (0.67) | MAPTPOLBGAAALDH1A1AKR1C3 | |
| SCHEMBL7882873 | 0.76 | MAPT (0.52) | MAPTPOLBGAAALDH1A1AKR1C3 | |
| SCHEMBL19527583 | 0.76 | MAPT (0.52) | MAPTPOLBGAAALDH1A1AKR1C3 | |
| SCHEMBL28195181 | 0.76 | MAPT (0.58) | MAPTPOLBGAAALDH1A1AKR1C3 | |
| Acetone SCHEMBL28526339 | 0.75 | POLB (0.62) | MAPTPOLBGAAALDH1A1AKR1C3 | |
| SCHEMBL11138887 | 0.73 | POLB (0.69) | MAPTPOLBGAAALDH1A1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645773-B2 | Thiazoles as inhibitors of 11β-hydroxysteroid dehydrogenase | HOFFMANN-LA ROCHE INC. (US) | 2010-01-12 | — | — | US | disclosed |