Valpromide

Valpromide

SCHEMBL35392

CCCC(CCC)C(N)=O

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 4/20 0.58
CA1 P00915 3/20 0.58
HDAC1 Q13547 2/20 0.57
HDAC2 Q92769 2/20 0.57
CHRM1 P11229 1/20 0.57
AKR1A1 P14550 1/20 0.57
CHRM3 P20309 1/20 0.57
HTR2A P28223 1/20 0.57
HTR2C P28335 1/20 0.57
ADRA1A P35348 1/20 0.57
HRH1 P35367 1/20 0.57
DRD3 P35462 1/20 0.57
SLC6A3 Q01959 1/20 0.57
TDP1 Q9NUW8 1/20 0.57
CYP3A4 P08684 2/20 0.55
TSHR P16473 2/20 0.55
NFKB1 P19838 2/20 0.55
NPSR1 Q6W5P4 2/20 0.55
HDAC7 Q8WUI4 2/20 0.50
HDAC8 Q9BY41 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Valpromide SCHEMBL28307837 0.97 CA2 (0.56) CA2CA1HDAC1HDAC2CHRM1
Valpromide SCHEMBL30601110 0.97 CA2 (0.56) CA2CA1HDAC1HDAC2CHRM1
Valpromide SCHEMBL3020937 0.97 CA2 (0.56) CA2CA1HDAC1HDAC2CHRM1
SCHEMBL14571349 0.90 CA2 (0.68) CA2CA1HDAC1HDAC2CHRM1
Valproic Acid SCHEMBL3336542 0.90 CHRM1 (0.76) CA2CA1HDAC1HDAC2CHRM1
SCHEMBL6947583 0.90 CA2 (0.75) CA2CA1HDAC1HDAC2CHRM1
SCHEMBL7859211 0.90 CA2 (0.50) CA2CA1HDAC1HDAC2CHRM1
SCHEMBL10776270 0.90 CA2 (0.50) CA2CA1HDAC1HDAC2CHRM1
SCHEMBL3349103 0.90 CA2 (0.75) CA2CA1HDAC1HDAC2CHRM1
SCHEMBL276427 0.89

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3640 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12544347-B2 Anti-cancer combination and a method of therapy using the combination NATIONAL CENTRE FOR CELL SCIENCE (IN) 2026-02-10 US claimed
EP-4648773-A1 POTASSIUM CHANNEL BLOCKERS OR DERIVATIVES THEREOF FOR PREVENTING, ALLEVIATING, AND/OR TREATING MORBIDITY AND MORTALITY INDUCED BY PATHOGENS OR OTHER INDUCERS OF IMMUNE EXHAUSTION AND/OR EXCESS IMMUNE ACTIVATION University of Rochester (US) 2025-11-19 EP claimed
US-20250346555-A1 METHOD FOR CO-PRODUCING VALPROAMIDE AND SODIUM VALPROATE HUNAN XIANGZHONG PHARMACEUTICAL CO LTD (CN) 2025-11-13 US claimed
CN-115968358-B Device for forming a cone for accommodating a needle in a syringe, method for manufacturing a cone for accommodating a needle in a syringe, and syringe thereof 斯蒂瓦那托集团股份公司 2025-05-23 CN claimed
EP-4551217-A1 POTASSIUM CHANNEL BLOCKERS OR DERIVATIVES THEREOF FOR PREVENTING, ALLEVIATING, AND/OR TREATING TISSUE DYSFUNCTION CAUSED BY TOXIC INSULTS University of Rochester (US) 2025-05-14 EP claimed
US-12285488-B2 Oral dosage form containing theobromine-free cocoa LTS LOHMANN THERAPIE-SYSTEME AG (DE) 2025-04-29 US claimed
EP-3518975-B1 FORMULATION COMPRISING FENFLURAMINE AND CANNABIDIOL AND ITS USE IN THE TREATMENT OF SEIZURES ZOGENIX INTERNATIONAL LTD (GB) 2025-04-09 EP claimed
CN-118373735-B Valproic acid prepared by cyanoacetic acid ester method 湖南省湘中制药有限公司 2025-02-21 CN claimed
EP-3846789-B1 COMPOSITION COMPRISING HISTONE DEACETYLASE INHIBITOR AND ESTROGEN RECEPTOR ANTAGONIST FOR USE IN A METHOD OF TREATMENT OF CANCER NAT CENTRE FOR CELL SCIENCE (IN) 2025-01-29 EP claimed
CN-118948849-A Medicine for preventing and treating diseases related to anti-obesity effect 盐野义制药株式会社 2024-11-15 CN claimed
US-5707663-A Sustained antiepileptic therapy ALZA CORPORATION (US) 1998-01-13 US claimed
WO-1994027587-A2 SUSTAINED ANTIEPILEPTIC THERAPY ALZA CORPORATION (US) 1994-12-08 WO claimed
EP-0505014-A2 Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use Sankyo Company Limited (JP) 1992-09-23 EP claimed
EP-0442012-A1 Sustained release compositions containing valproic acid YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1991-08-21 EP claimed
US-4913906-A DRUG DELIVERY; UNIFORM MIXTURE WITH POLYMER; ALSO SALTS, AMIDES, ESTERS ABBOTT LABORATORIES 1990-04-03 US claimed
US-4854973-A SHORT CHAIN CHLORINATED SOLVENTS NCH CORPORATION (US) 1989-08-08 US claimed
EP-0205362-A1 Quinolyl glycinamide derivatives, process for their preparation and their pharmaceutical use as psychotropes SANOFI (FR) 1986-12-17 EP claimed
EP-0028940-B1 ANTIARRHYTHMIC TETRAHYDRONAPHTHALENE DERIVATIVES E.R. Squibb & Sons, Inc. (US) 1983-09-07 EP claimed
EP-0024682-B1 PROCESS FOR THE PREPARATION OF N-PROPYL-N-PROPYLIDENE ACETAMIDE OR DI-N-PROPYL ACETAMIDE Consortium für elektrochemische Industrie GmbH (DE) 1982-12-22 EP claimed
EP-0024682-A1 Process for the preparation of n-propyl-n-propylidene acetamide or di-n-propyl acetamide Consortium für elektrochemische Industrie GmbH (DE) 1981-03-11 EP claimed