Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 11/20 | 0.66 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.41 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.39 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3537833 | 1.00 | HTR2C (0.66) | HTR2CTLR7PANK3TRPC3TRPC6 | |
| SCHEMBL3539684 | 0.83 | PTGDR2 (0.48) | HTR2CTRPC3TRPC6SCD5ALDH1A1 | |
| SCHEMBL3542012 | 0.83 | HTR2C (0.43) | HTR2CTRPC3TRPC6SCD5 | |
| SCHEMBL3545036 | 0.82 | ALDH1A1 (0.46) | HTR2CTRPC3TRPC6ALDH1A1NPC1 | |
| SCHEMBL3536849 | 0.81 | HTR2C (0.60) | HTR2CTLR7PANK3TRPC3TRPC6 | |
| SCHEMBL3537336 | 0.78 | HTR2C (1.00) | HTR2CTLR7PANK3ALDH1A1NPC1 | |
| SCHEMBL3537862 | 0.78 | HTR2C (1.00) | HTR2CTLR7PANK3ALDH1A1NPC1 | |
| SCHEMBL3537831 | 0.77 | HTR2C (0.72) | HTR2CTLR7PANK3TRPC3TRPC6 | |
| SCHEMBL3543127 | 0.77 | HTR2C (0.72) | HTR2CTLR7PANK3TRPC3TRPC6 | |
| SCHEMBL3547001 | 0.77 | PIM1 (0.41) | HTR2CTRPC3TRPC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | claimed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | claimed |
| US-7645773-B2 | Thiazoles as inhibitors of 11β-hydroxysteroid dehydrogenase | HOFFMANN-LA ROCHE INC. (US) | 2010-01-12 | — | — | US | disclosed |
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | disclosed |