Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mefenamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 4/20 | 1.00 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | AKR1B10 | O60218 | 3/20 | 1.00 |
| ▸ | AKR1C2 | P52895 | 3/20 | 1.00 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | AKR1B1 | P15121 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | TRPA1 | O75762 | 1/20 | 1.00 |
| ▸ | DHFR | P00374 | 1/20 | 1.00 |
| ▸ | MPO | P05164 | 1/20 | 1.00 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mefenamic Acid SCHEMBL29355128 | 1.00 | PTGS2 (1.00) | PTGS2AKR1C3LMNAMEN1KMT2A | |
| Mefenamic Acid SCHEMBL29465887 | 1.00 | PTGS2 (1.00) | PTGS2AKR1C3LMNAMEN1KMT2A | |
| Mefenamic Acid SCHEMBL29350572 | 1.00 | PTGS2 (1.00) | PTGS2AKR1C3LMNAMEN1KMT2A | |
| Mefenamic Acid SCHEMBL6421234 | 1.00 | PTGS2 (1.00) | PTGS2AKR1C3LMNAMEN1KMT2A | |
| Mefenamic Acid SCHEMBL27396077 | 0.98 | PTGS2 (0.97) | PTGS2AKR1C3LMNAMEN1KMT2A | |
| Mefenamic Acid SCHEMBL27621964 | 0.98 | PTGS2 (0.97) | PTGS2AKR1C3LMNAMEN1KMT2A | |
| Mefenamic Acid SCHEMBL28663310 | 0.98 | PTGS2 (0.97) | PTGS2AKR1C3LMNAMEN1KMT2A | |
| Mefenamic Acid SCHEMBL29282578 | 0.98 | PTGS2 (0.97) | PTGS2AKR1C3LMNAMEN1KMT2A | |
| Mefenamic Acid SCHEMBL28036729 | 0.98 | PTGS2 (0.97) | PTGS2AKR1C3LMNAMEN1KMT2A | |
| Mefenamic Acid SCHEMBL678182 | 0.98 | PTGS2 (0.97) | PTGS2AKR1C3LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 60866 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747263-A1 | LIPID NANOPARTICLES AND USES THEREOF | University of Connecticut (US) | 2026-05-27 | — | — | EP | claimed |
| US-20260138973-A1 | SUBSTITUTED PYRIDINES FOR USE IN TREATING OR PREVENTING INFLAMMATORY DISEASES OR DISEASES ASSOCIATED WITH AN UNDESIRABLE IMMUNE RESPONSE | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| US-20260137680-A1 | NOVEL COMPOUNDS | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| EP-3841097-B1 | 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER | BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) | 2026-05-20 | — | — | EP | claimed |
| CN-120682231-B | Mefenamic acid-aloperine co-amorphous substance and preparation method and application thereof | 中国食品药品检定研究院 | 2026-05-15 | — | — | CN | claimed |
| US-20260130928-A1 | COMBINATION OF AKR1C3 ACTIVATED ANTICANCER PRODRUG COMPOUND AND ANALGESIC DRUG FOR TREATING CANCER PATIENTS ACCOMPANIED BY PAIN | ASCENTAWITS PHARMACEUTICALS LTD (CN) | 2026-05-14 | — | — | US | claimed |
| CN-122005814-A | Drug-loaded polymer micelle, gel drug system, preparation method and application | 苏州大学 | 2026-05-12 | — | — | CN | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| EP-4731194-A1 | MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT | CSP Technologies, Inc. (US) | 2026-04-29 | — | — | EP | claimed |
| US-12605462-B2 | Porous silicon nanoparticle-based drug delivery system inducing reactive oxygen species and self-activation thereof, and method for preparing same | UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY (KR) | 2026-04-21 | — | — | US | claimed |
| EP-0051278-A1 | Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1982-05-12 | — | — | EP | claimed |
| EP-0050385-A1 | Piridoxine derivatives, a process for their preparation and related pharmaceutical compositions | D and D S.r.l. (IT) | 1982-04-28 | — | — | EP | claimed |
| EP-0005207-B1 | BIS-1:2 CHROME-DISAZO-BISAZO METHINE DYESTUFFS, THEIR PREPARATION AND USE FOR DYEING OF LEATHER | CIBA-GEIGY AG (CH) | 1981-12-09 | — | — | EP | claimed |
| EP-0039051-A2 | Mannich-base hydroxamic acid prodrugs for the improved bioavailability of non-steroidal anti-inflammatory agents, a process for preparing and a pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1981-11-04 | — | — | EP | claimed |
| EP-0036138-A2 | Composition of matter for topical application comprising a bio-affecting agent and N,N-diethyl-m-toluamide | MERCK & CO. INC. (US) | 1981-09-23 | — | — | EP | claimed |
| US-4268685-A | Salicylamide esters and related pharmaceutical composition | NEOPHARMED S.P.A. (IT) | 1981-05-19 | — | — | US | claimed |
| US-4260613-A | ANTIINFLAMMATORY, ANTIPYRETIC, ANALGESIC | CRINOS INDUSTRIA FARMACOBIOLOGICA S.P.A. (IT) | 1981-04-07 | — | — | US | claimed |
| US-4247554-A | ADMINISTERING A QUINAZOLINONE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-01-27 | — | — | US | claimed |
| EP-0016460-A1 | Salicylamide esters having therapeutical activity, process for their preparation and related pharmaceutical composition | NEOPHARMED S.p.A. (IT) | 1980-10-01 | — | — | EP | claimed |
| US-4024279-A | Treatment of dysmenorrhea and migraine symptoms | YEDA RESEARCH & DEVELOPMENT CO. LTD. (IL) | 1977-05-17 | — | — | US | claimed |