Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | STS | P08842 | 8/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548915 | 0.92 | STS (0.40) | MIFCA2CA9STSCA1 | |
| SCHEMBL3543484 | 0.86 | STS (0.40) | MIFCA2CA9STSCA1 | |
| SCHEMBL2784133 | 0.83 | CA2 (0.42) | CA2CA9STSKMT2ACA1 | |
| SCHEMBL3543201 | 0.82 | MIF (0.50) | MIFCA2CA9STSCA1 | |
| SCHEMBL2766273 | 0.82 | STS (0.43) | MIFCA2CA9STSCA1 | |
| SCHEMBL3628429 | 0.81 | CA2 (0.41) | MIFCA2CA9ALDH1A1KMT2A | |
| SCHEMBL3548006 | 0.80 | MIF (0.50) | MIFCA2CA9STSCA1 | |
| SCHEMBL3546808 | 0.80 | CA2 (0.45) | MIFCA2CA9STSCA1 | |
| SCHEMBL3627755 | 0.80 | MIF (0.67) | MIFALDH1A1KMT2AHPGDCASP1 | |
| SCHEMBL3545608 | 0.79 | MIF (0.46) | MIFCA2CA9STSCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795251-B2 | 3,4-dihydro-benzo[e][1,3]oxazin-2-ones | NOVARTIS AG (CH) | 2010-09-14 | — | — | US | disclosed |
| EP-1874742-A1 | 3,4-DIHYDRO-BENZO[E][1,3]OXAZIN-2-ONES | Novartis AG (CH) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006108671-A1 | 3,4-DIHYDRO-BENZO[E][1,3]OXAZIN-2-ONES | NOVARTIS AG (CH) | 2006-10-19 | — | — | WO | disclosed |