Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 4/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.35 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.35 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3756039 | 0.76 | CYP3A4 (0.46) | AOC3TXNRD1TXNRD3TXNRD2GABRA1 | |
| SCHEMBL11849090 | 0.73 | CYP3A4 (0.46) | GABRA1GABRB2TDP1ALDH1A1CYP3A4 | |
| SCHEMBL30884742 | 0.68 | TDP1 (0.44) | AOC3TXNRD1TXNRD3TXNRD2TDP1 | |
| SCHEMBL14370481 | 0.68 | AOC3 (0.42) | AOC3TXNRD1TXNRD3TXNRD2TDP1 | |
| SCHEMBL5958793 | 0.68 | TDP1 (0.44) | AOC3TXNRD1TXNRD3TXNRD2TDP1 | |
| SCHEMBL170732 | 0.67 | TXNRD1 (0.37) | AOC3TXNRD1TXNRD3TXNRD2TDP1 | |
| SCHEMBL8587914 | 0.67 | NQO2 (0.44) | AOC3TXNRD1TXNRD3TXNRD2ALDH1A1 | |
| SCHEMBL1479642 | 0.67 | TXNRD1 (0.37) | AOC3TXNRD1TXNRD3TXNRD2TDP1 | |
| SCHEMBL1493105 | 0.67 | TDP1 (0.44) | GABRA1GABRB2TDP1ALDH1A1CYP3A4 | |
| SCHEMBL767958 | 0.67 | AOC3 (0.50) | AOC3TXNRD1TXNRD3TXNRD2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741479-B2 | Urea inhibitors of MAP kinases | LOCUS PHARMACEUTICALS, INC. (US) | 2010-06-22 | — | — | US | disclosed |
| US-20060167247-A1 | Urea inhibitors of MAP kinases | LOCUS PHARMACEUTICALS, INC. | 2006-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167247-A1 | Urea inhibitors of MAP kinases | MAPK1, MAP3K1, MAP3K20 | AOC3 2221/4885TXNRD1 969/4885TXNRD3 916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.