Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 14/20 | 0.50 |
| ▸ | PLK3 | Q9H4B4 | 6/20 | 0.46 |
| ▸ | PLK2 | Q9NYY3 | 6/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | SELP | P16109 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3540805 | 0.91 | PLK1 (0.60) | PLK1PLK3PLK2LRRK2BRD4 | |
| SCHEMBL3544823 | 0.88 | PLK1 (0.61) | PLK1PLK3PLK2BRD4BRDT | |
| SCHEMBL3541574 | 0.88 | PLK1 (0.53) | PLK1PLK3PLK2LRRK2BRD4 | |
| SCHEMBL3545836 | 0.83 | PLK1 (0.60) | PLK1PLK3PLK2BRD4BRDT | |
| SCHEMBL3540861 | 0.82 | PLK1 (0.59) | PLK1PLK3PLK2BRD4BRDT | |
| SCHEMBL3545591 | 0.82 | PLK1 (0.52) | PLK1PLK3PLK2LRRK2BRD4 | |
| SCHEMBL3541132 | 0.81 | PLK1 (0.56) | PLK1PLK3PLK2LRRK2BRD4 | |
| SCHEMBL3541137 | 0.81 | PLK1 (0.56) | PLK1PLK3PLK2LRRK2BRD4 | |
| SCHEMBL3544305 | 0.81 | PLK1 (0.74) | PLK1PLK3PLK2BRD4BRDT | |
| SCHEMBL3549663 | 0.80 | PLK1 (0.55) | PLK1PLK3PLK2MAP4K4BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709471-B2 | Compounds | ASTRAZENECA AB (SE) | 2010-05-04 | — | — | US | disclosed |
| US-20080009482-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009482-A1 | NOVEL COMPOUNDS | CYP11B2, CYP11B1, CYP46A1 | PLK1 847/4885PLK3 2136/4885PLK2 1286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.