Sugi Predict

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SCHEMBL3545923

SCHEMBL3545923

CN1CCN(c2ccc(NC(=O)C(F)(F)F)c(N3CCCCC3)c2)CC1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 9/20 0.61
▸ ALDH1A1 P00352 2/20 0.50
▸ GAA P10253 2/20 0.47
▸ MAPT P10636 2/20 0.47
▸ MAPK1 P28482 2/20 0.47
▸ HTT P42858 2/20 0.47
▸ KDM4E B2RXH2 1/20 0.47
▸ RECQL P46063 1/20 0.47
▸ PTK2B Q14289 1/20 0.47
▸ BRPF1 P55201 2/20 0.46
▸ HDAC3 O15379 1/20 0.45
▸ HDAC8 Q9BY41 1/20 0.45
▸ NTRK1 P04629 1/20 0.45
▸ KIT P10721 1/20 0.45
▸ AXL P30530 1/20 0.45
▸ FLT3 P36888 1/20 0.45
▸ MEN1 O00255 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ WDR5 P61964 1/20 0.43
▸ LMNA P02545 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3539481 0.88 CSF1R (0.54) CSF1RGAAMAPTMAPK1HTT
Trifluoroacetic Acid SCHEMBL3545926 0.80 MAPT (0.66) CSF1RALDH1A1GAAMAPTMAPK1
SCHEMBL31157975 0.76 CSF1R (0.56) CSF1RALDH1A1MAPTMAPK1HDAC3
SCHEMBL13405631 0.76 CSF1R (1.00) CSF1RKIT
SCHEMBL3543649 0.76 CSF1R (0.66) CSF1RALDH1A1GAANTRK1KIT
SCHEMBL23293521 0.76 CSF1R (0.56) CSF1RALDH1A1MAPTMAPK1HDAC3
SCHEMBL31157967 0.76 CSF1R (1.00) CSF1RKIT
SCHEMBL31157983 0.76 CSF1R (1.00) CSF1RKIT
SCHEMBL13767329 0.76 CSF1R (0.75) CSF1RALDH1A1GAAMAPTMAPK1
SCHEMBL31000448 0.76 CSF1R (0.55) CSF1RALDH1A1HDAC3HDAC8NTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7705042-B2 Class of arylamide compounds useful as inhibitors of c-fms kinase JANSSEN PHARMACEUTICA NV (BE) 2010-04-27 — — US claimed
EP-1807407-B1 AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA NV (BE) 2009-07-29 — — EP claimed
EP-1807407-A1 AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-07-18 — — EP claimed
US-20060100201-A1 Inhibitors of c-fms kinase JANSSEN PHARMACEUTICA, N.V. (BE) 2006-05-11 — — US claimed
WO-2006047504-A1 AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA, N.V. (BE) 2006-05-04 — — WO claimed
US-7705042-B2 Class of arylamide compounds useful as inhibitors of c-fms kinase JANSSEN PHARMACEUTICA NV (BE) 2010-04-27 — — US disclosed
EP-1807407-B1 AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA NV (BE) 2009-07-29 — — EP disclosed
EP-1807407-A1 AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-07-18 — — EP disclosed
US-20060100201-A1 Inhibitors of c-fms kinase JANSSEN PHARMACEUTICA, N.V. (BE) 2006-05-11 — — US disclosed
WO-2006047504-A1 AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA, N.V. (BE) 2006-05-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060100201-A1 Inhibitors of c-fms kinase MUSK, FLT3, FES CSF1R 34/4885ALDH1A1 4796/4885GAA 3696/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.