SCHEMBL3546141

SCHEMBL3546141

O=C(O)c1ccc(OCCc2c(CCNS(=O)(=O)c3c(F)cccc3F)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1

nearest known ligand 0.82

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PLA2G4A P47712 20/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3551421 0.95 PLA2G4A (0.81) PLA2G4A
SCHEMBL1500996 0.94 PLA2G4A (0.75) PLA2G4A
SCHEMBL3551663 0.93 PLA2G4A (0.82) PLA2G4A
SCHEMBL3555812 0.93 PLA2G4A (0.84) PLA2G4A
SCHEMBL82929 0.91 PLA2G4A (0.84) PLA2G4A
SCHEMBL1501002 0.91 PLA2G4A (0.82) PLA2G4A
SCHEMBL1500977 0.91 PLA2G4A (0.84) PLA2G4A
SCHEMBL1501234 0.91 PLA2G4A (0.81) PLA2G4A
SCHEMBL1501219 0.91 PLA2G4A (0.81) PLA2G4A
SCHEMBL82699 0.90 PLA2G4A (1.00) PLA2G4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1892239-B1 Inhibitors of cytosolic phospholipase A2 WYETH LLC (US) 2013-02-20 EP claimed
US-7713964-B2 Methods for treating asthmatic conditions WYETH LLC (US) 2010-05-11 US claimed
US-7605156-B2 Methods for the use of inhibitors of cytosolic phospholipase A2 WYETH (US) 2009-10-20 US claimed
EP-1892239-B1 Inhibitors of cytosolic phospholipase A2 WYETH LLC (US) 2013-02-20 EP disclosed
US-7605156-B2 Methods for the use of inhibitors of cytosolic phospholipase A2 WYETH (US) 2009-10-20 US disclosed
EP-1451154-B1 INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 WYETH CORP (US) 2008-01-16 EP disclosed