⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10417495 | 0.81 | KDM4E (0.55) | — | |
| SCHEMBL5319584 | 0.79 | — | — | |
| SCHEMBL353929 | 0.79 | — | — | |
| SCHEMBL353705 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL11657154 | 0.77 | KDM4E (0.52) | — | |
| SCHEMBL11555065 | 0.76 | KDM4E (0.50) | — | |
| SCHEMBL4441896 | 0.74 | ALDH1A1 (0.37) | — | |
| SCHEMBL3060862 | 0.74 | — | — | |
| SCHEMBL11193443 | 0.74 | KDM4E (0.49) | — | |
| SCHEMBL43076 | 0.74 | KDM4E (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117800942-B | Thiophene piperazine amide derivative, composition and application thereof | 徐州医科大学 | 2025-04-25 | — | — | CN | disclosed |
| CN-113490668-B | Compounds and compositions for the treatment of diseases associated with APJ receptor activity | 安娜普尔纳生物股份有限公司 | 2025-02-25 | — | — | CN | disclosed |
| WO-2024138109-A2 | PHENYL-PYRAZOLE CARBOXAMIDE COMPOUNDS | ACRIVON THERAPEUTICS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| CN-117800942-A | Thiophene piperazine amide derivative, composition and application thereof | 徐州医科大学 | 2024-04-02 | — | — | CN | disclosed |
| EP-2200440-B1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | CRESTONE INC (US) | 2017-07-19 | — | — | EP | disclosed |
| CN-104140421-B | Benzo isothiazole compound and the application in antipsychotic drug is prepared | 上海医药工业研究院 | 2017-04-05 | — | — | CN | disclosed |
| EP-2325181-B1 | STAT3 INHIBITOR CONTAINING QUINOLINECARBOXAMIDE DERIVATIVE AS ACTIVE INGREDIENT | GENERAL INCORPORATED ASS PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) | 2017-03-29 | — | — | EP | disclosed |
| US-9493489-B2 | Boron-containing small molecules as anti-protozoal agents | ANACOR PHARMACEUTICALS, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| US-9321766-B1 | Kinase inhibitors | ALLERGAN, INC. (US) | 2016-04-26 | — | — | US | disclosed |
| US-20160096832-A1 | KINASE INHIBITORS | ALLERGAN, INC. | 2016-04-07 | — | — | US | disclosed |
| US-4128548-A | Process for preparing 6,7-benzomorphans | ACF CHEMIEFARMA N.V. (NL) | 1978-12-05 | — | — | US | disclosed |
| US-4069328-A | ANALGESICS, MORPHINE-ANTAGONISTS | BOEHRINGER INGELHEIM GMBH (DT) | 1978-01-17 | — | — | US | disclosed |
| US-4004010-A | ANALGESIC, ANTITUSSIVE | BOEHRINGER INGELHEIM GMBH (DT) | 1977-01-18 | — | — | US | disclosed |
| US-3998960-A | ANALGESIC, ANTITUSSIVE, OPIATE ANTAGONIST | BOEHRINGER INGELHEIM GMBH (DT) | 1976-12-21 | — | — | US | disclosed |
| US-3992542-A | Pharmaceutical compositions containing an N-(furyl-methyl)-6,14-(endoethano or endoetheno)-7α-hydroxyalkyl-tetrahydro-noroipavine or -northebaine and method of use | BOEHRINGER INGELHEIM GMBH (DT) | 1976-11-16 | — | — | US | disclosed |
| US-3975368-A | OPIATE ANTAGONIST, ANALGESICE, ANTITUSSIVE | BOEHRINGER INGELHEIM GMBH (DT) | 1976-08-17 | — | — | US | disclosed |
| US-3962249-A | 1-(3-PHENYLPROPYL)-4-FUROYLPIPERAZINE DERIVATIVES | KYORIN SEIYAKU KABUSHIKI KAISHA (JA) | 1976-06-08 | — | — | US | disclosed |
| US-3931194-A | ANALGESIC, ANTITUSSIVE, OPIATE ANTAGONIST | BOEHRINGER INGELHEIM GMBH (DT) | 1976-01-06 | — | — | US | disclosed |
| US-3931187-A | ANALGESIC, ANTITUSSIVE | BOEHRINGER INGELHEIM GMBH (DT) | 1976-01-06 | — | — | US | disclosed |
| US-3931189-A | ANALGESIC, ANTITUSSIVE | BOEHRINGER INGELHEIM GMBH (DT) | 1976-01-06 | — | — | US | disclosed |